Antiphospholipid syndrome: State of the art on clinical practice guidelines

Marteen Limper, Carlo Alberto Scirè, Rosaria Talarico, Zahir Amoura, Tadej Avcin, Martina Basile, Gerd Burmester, Linda Carli, Ricard Cervera, Nathalie Costedoat-Chalumeau, Andrea Doria, Thomas Dörner, João Eurico Fonseca, Ilaria Galetti, Eric Hachulla, David Launay, Filipa Lourenco, Carla Macieira, Pierluigi Meroni, Carlo Maurizio MontecuccoMaria Francisca Moraes-Fontes, Luc Mouthon, Cecilia Nalli, Veronique Ramoni, Maria Tektonidou, Jacob M. Van Laar, Stefano Bombardieri, Matthias Schneider, Vanessa Smith, Ana Vieira, Maurizio Cutolo, Marta Mosca, Angela Tincani

Research output: Contribution to journalReview article

Abstract

Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers.

Original languageEnglish
Article numbere000785
JournalRMD Open
Volume4
DOIs
Publication statusPublished - Oct 1 2018

Keywords

  • antiphospholipid syndrome
  • clinical practice guidelines
  • ERN ReCONNET
  • European reference networks
  • unmet needs

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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  • Cite this

    Limper, M., Scirè, C. A., Talarico, R., Amoura, Z., Avcin, T., Basile, M., Burmester, G., Carli, L., Cervera, R., Costedoat-Chalumeau, N., Doria, A., Dörner, T., Fonseca, J. E., Galetti, I., Hachulla, E., Launay, D., Lourenco, F., Macieira, C., Meroni, P., ... Tincani, A. (2018). Antiphospholipid syndrome: State of the art on clinical practice guidelines. RMD Open, 4, [e000785]. https://doi.org/10.1136/rmdopen-2018-000785