Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus

Matteo Iannacone, Giovanni Sitia, Iñigo Narvaiza, Zaverio M. Ruggeri, Luca G. Guidotti

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.

Original languageEnglish
Pages (from-to)1532-1535
Number of pages4
JournalClinical and Vaccine Immunology
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 2007

Fingerprint

clopidogrel
Drug therapy
Platelet Aggregation Inhibitors
Adenoviridae
Liver
Aspirin
Liver Diseases
Viruses
Drug Therapy
Gene therapy
T-cells
Cytotoxic T-Lymphocytes
Platelets
Genetic Therapy
Anemia
Leukocytes
Blood Platelets
Hemorrhage

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

@article{2b881caebf264f8aa73040a6315abed6,
title = "Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus",
abstract = "Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.",
author = "Matteo Iannacone and Giovanni Sitia and I{\~n}igo Narvaiza and Ruggeri, {Zaverio M.} and Guidotti, {Luca G.}",
year = "2007",
month = "11",
doi = "10.1128/CVI.00298-07",
language = "English",
volume = "14",
pages = "1532--1535",
journal = "Clinical and Vaccine Immunology",
issn = "1556-6811",
publisher = "American Society for Microbiology",
number = "11",

}

TY - JOUR

T1 - Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus

AU - Iannacone, Matteo

AU - Sitia, Giovanni

AU - Narvaiza, Iñigo

AU - Ruggeri, Zaverio M.

AU - Guidotti, Luca G.

PY - 2007/11

Y1 - 2007/11

N2 - Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.

AB - Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.

UR - http://www.scopus.com/inward/record.url?scp=37349096941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349096941&partnerID=8YFLogxK

U2 - 10.1128/CVI.00298-07

DO - 10.1128/CVI.00298-07

M3 - Article

C2 - 17881509

AN - SCOPUS:37349096941

VL - 14

SP - 1532

EP - 1535

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

SN - 1556-6811

IS - 11

ER -