Abstract
Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 1532-1535 |
| Number of pages | 4 |
| Journal | Clinical and Vaccine Immunology |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2007 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Immunology
- Immunology and Allergy
- Microbiology (medical)
Cite this
Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus. / Iannacone, Matteo; Sitia, Giovanni; Narvaiza, Iñigo; Ruggeri, Zaverio M.; Guidotti, Luca G.
In: Clinical and Vaccine Immunology, Vol. 14, No. 11, 11.2007, p. 1532-1535.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus
AU - Iannacone, Matteo
AU - Sitia, Giovanni
AU - Narvaiza, Iñigo
AU - Ruggeri, Zaverio M.
AU - Guidotti, Luca G.
PY - 2007/11
Y1 - 2007/11
N2 - Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.
AB - Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=37349096941&partnerID=8YFLogxK
U2 - 10.1128/CVI.00298-07
DO - 10.1128/CVI.00298-07
M3 - Article
C2 - 17881509
AN - SCOPUS:37349096941
VL - 14
SP - 1532
EP - 1535
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
SN - 1556-6811
IS - 11
ER -