Antiplatelet therapy and outcome in patients undergoing surgery following coronary stenting: Results of the surgery after stenting registry

R. Rossini, D. J. Angiolillo, G. Musumeci, D. Capodanno, M. Lettino, D. Trabattoni, A. Pilleri, P. Calabria, P. Colombo, P. Bernabo, M. Ferlini, M. Ferri, G. Tarantini, S. De Servi, S. Savonitto

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: The aim of the present study was to define the feasibility and clinical impact of complying with national consensus recommendations on perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and noncardiac surgery. BACKGROUND: There are limited evidence-based recommendations on the perioperative management of antiplatelet therapy in stented patients undergoing surgery. METHODS: The recommendations provided by the national consensus document were applied in a multicenter, prospective registry of consecutive patients with prior coronary stenting undergoing any type of surgery at 19 hospitals in Italy. The primary end-point was in-hospital net adverse clinical events (NACE) represented by the composite of all-cause death, myocardial infarction, probable/definite stent thrombosis and Bleeding Academic Research Consortium (BARC) grade >/=3 bleeding. Patients were followed for 30 days. RESULTS: A total of 1,082 patients were enrolled. Adherence to consensus recommendations occurred in 85% of the cases. Perioperative aspirin and dual antiplatelet therapy were maintained in 69.7 and 10.5% of the cases, respectively. In-hospital NACE rate was 12.7%, being significantly higher in patients undergoing cardiac surgery (36.3% vs. 7.3%, P /=3 bleeding events were significantly higher with cardiac surgery (36.3% vs. 5.6%, P <0.01). CONCLUSIONS: The results of this registry demonstrate the safety and feasibility of applying a national consensus document on the perioperative management of antiplatelet therapy in stented patients undergoing surgery. (c) 2016 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)E13-E25
JournalCatheterization and Cardiovascular Interventions
Volume89
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Aged
  • Aged, 80 and over
  • Cardiac Surgical Procedures/adverse effects/standards
  • Consensus
  • Coronary Thrombosis/etiology
  • Drug Therapy, Combination
  • Feasibility Studies
  • Female
  • Guideline Adherence
  • Hemorrhage/chemically induced
  • Hospital Mortality
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Myocardial Infarction/etiology
  • Percutaneous Coronary Intervention/adverse effects/instrumentation/mortality/standards
  • Platelet Aggregation Inhibitors/adverse effects/therapeutic use
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians'/standards
  • Prospective Studies
  • Registries
  • Risk Factors
  • Stents
  • Time Factors
  • Treatment Outcome
  • antiplatelet therapy
  • bleeding
  • ischemia
  • stent
  • surgery

Fingerprint Dive into the research topics of 'Antiplatelet therapy and outcome in patients undergoing surgery following coronary stenting: Results of the surgery after stenting registry'. Together they form a unique fingerprint.

Cite this