Antiproliferative effects of novel aliphatic acetogenin analogs against aggressive solid tumor cell lines

Leticia G. León, Elisa Giovannetti, Claudia Alecci, Fiorella Giancola, Niccola Funel, Paolo Zucali, Godefridus J. Peters, José M. Padrón

Research output: Contribution to journalArticlepeer-review

Abstract

The antiproliferative effects of three synthetic analogs of aliphatic acetogenins selected from a previous screening were compared to those of the drugs used for the treatment of malignant pleural mesothelioma (MPM) and pancreatic ductal adenocarcinoma (PDAC). Materials and Methods: Four PDAC and three MPM cell lines were used in the study. Cell growth inhibition was determined after 48 h exposure to the drugs. Cell-cycle disruption and apoptosis induction were studied by flow cytometry. The modulation of Akt phosphorylation was studied using a specific ELISA for P-Ser473 Akt. Results: The new compounds inhibited cell growth, induced apoptosis and cell-cycle abrogation in all cell lines. Phosphorylated Akt levels rose after treatment. Conclusion: The results demonstrated better performance of aliphatic acetogenin analogs against PDAC cells when compared to standard anticancer drugs. For MPM cells, the application of the new compounds may play an important role in overcoming the resistance to conventional treatments.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalIn Vivo
Volume25
Issue number2
Publication statusPublished - Mar 2011

Keywords

  • Aliphatic acetogenins
  • Anticancer drugs
  • Cell cycle
  • Mesothelioma
  • Pancreas cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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