Antipsychotic augmentation of selective serotonin reuptake inhibitors in resistant tic-related obsessive-compulsive disorder in children and adolescents: Anaturalistic comparative study

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Abstract

The aim of this study is to assess efficacy of augmentation of SSRIs with risperidone or aripiprazole in youths with tic-related Obsessive-Compulsive Disorder (OCD) non responders to an SSRI monotherapy. 120 consecutive patients (age range 7-18 years) were treated with an SSRI monotherapy for at least 12 weeks, 51 (42.5%) were responders, and the 69 non-responders (mean age 13.7±2.4 years) were included in this study. 35 patients received an augmentation with risperidone (1.7±.8mg/day), and 34 with aripiprazole (8.9±3.1mg/day) for 12 weeks. Regarding the OCD symptomatology, at the endpoint the Clinical Global Impression-Severity score (CGI-S) improved from 5.6±.8 (severely ill), to 3.2±.9 (mild to moderately ill) (p

Original languageEnglish
Pages (from-to)1007-1012
Number of pages6
JournalJournal of Psychiatric Research
Volume47
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Adolescents
  • Aripiprazole
  • Children
  • Obsessive-compulsive disorder
  • Risperidone
  • Tic disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Arts and Humanities (miscellaneous)

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