Objectives: Patterns of clinical use of antipsychotic agents have largely changed in the past decade. The aim of the study was to assess these patterns in all inpatients of the Milan Psychiatric Clinic (Ospedale Maggiore) during 1989 (N = 350). 1999 (N = 718) and 2002 (N = 628). Methods: We reviewed all clinical records to determine inpatients' sex, age. ICD-9 diagnosis at discharge and drug intake, its dosing and timing. Results: In 2002, atypical antipsychotics as monotherapy at discharge were prescribed most frequently (52.98%), compared to the classical ones (47.02%). Combinations of two or more antipsychotic drugs were prescribed at discharge in 20.63% of the patients in 1989, in 31.24% in 1999, and in 23.09% in 2002. The combination of a typical with an atypical drug increased from 15.26% in 1999 to 42.26% in 2002. The use of classical neuroleptics is maintained mainly for low potency neuroleptics. The average daily dosage of antipsychotic drugs, expressed as chlorpromazine equivalents, was significantly greater in 2002 (220,56 mg ± 9.44 SD) than in the 1999 (199,21 mg ± 6.21 SD) (p <0.05). Conclusions: The present study confirm the emerging trends toward higher total antipsychotic doses and polypharmacy.
|Translated title of the contribution||Antipsychotic drug use at the inpatient unit of the Milan Psychiatric Clinic (Ospedale Maggiore) during 1989, 1999 and 2002|
|Number of pages||9|
|Journal||Italian Journal of Psychopathology|
|Publication status||Published - Jun 2004|
ASJC Scopus subject areas
- Psychiatry and Mental health