Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: Results of the exercise in left ventricular dysfunction and chronic heart failure (ELVD-CHF) trial

Pantaleo Giannuzzi, Pier Luigi Temporelli, Ugo Corrà, Luigi Tavazzi

Research output: Contribution to journalArticle

Abstract

Background - The effects of exercise training (ET) on left ventricular (LV) remodeling in chronic heart failure are not definitively established, and the safety of ET in these patients is still debated. Methods and Results - This multicenter study investigated the long-term effect of moderate ET on LV remodeling, work capacity, and quality of life (QoL) in 90 patients with stable chronic heart failure caused by LV systolic dysfunction, randomized to a 6-month ET program (T, n=45) or a control group (C, n=45). All patients underwent resting echocardiography, a cardiopulmonary exercise test, 6-minute walking test, and QoL assessment at entry and after 6 months. At entry, end-diastolic (EDV) and end-systolic (ESV) volume, ejection fraction, work capacity, peak V̇o2, and walking distance were similar in the 2 groups. After 6 months, LV volumes diminished in T (EDV, from 142±26 to 135±26 mL/m2, P2, P2, P2, P2 (P

Original languageEnglish
Pages (from-to)554-559
Number of pages6
JournalCirculation
Volume108
Issue number5
DOIs
Publication statusPublished - Aug 5 2003

Keywords

  • Exercise
  • Heart failure
  • Remodeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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