TY - JOUR
T1 - Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naïve HIV individuals
AU - Babiloni, Claudio
AU - Pennica, Alfredo
AU - Del Percio, Claudio
AU - Noce, Giuseppe
AU - Cordone, Susanna
AU - Lopez, Susanna
AU - Berry, Ketura
AU - Muratori, Chiara
AU - Ferracuti, Stefano
AU - Roma, Paolo
AU - Correr, Valentina
AU - Di Campli, Francesco
AU - Gianserra, Laura
AU - Ciullini, Lorenzo
AU - Aceti, Antonio
AU - Soricelli, Andrea
AU - Teti, Elisabetta
AU - Viscione, Magdalena
AU - Limatola, Cristina
AU - Onorati, Paolo
AU - Capotosto, Paolo
AU - Andreoni, Massimo
PY - 2016
Y1 - 2016
N2 - Objective Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. Methods Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual. They also included beta1 (13–20 Hz) and beta2 (20–30 Hz). Low-resolution brain electromagnetic tomography (LORETA) estimated EEG cortical source activity in frontal, central, temporal, parietal, and occipital regions. Results Before the therapy, the HIV group showed greater parietal delta source activity and lower spatially diffuse alpha source activity compared to the control group. Thus, the ratio of parietal delta and alpha3 source activity served as an EEG marker. The z-score showed a statistically deviant EEG marker (EEG +) in 50% of the HIV individuals before therapy (p
AB - Objective Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. Methods Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual. They also included beta1 (13–20 Hz) and beta2 (20–30 Hz). Low-resolution brain electromagnetic tomography (LORETA) estimated EEG cortical source activity in frontal, central, temporal, parietal, and occipital regions. Results Before the therapy, the HIV group showed greater parietal delta source activity and lower spatially diffuse alpha source activity compared to the control group. Thus, the ratio of parietal delta and alpha3 source activity served as an EEG marker. The z-score showed a statistically deviant EEG marker (EEG +) in 50% of the HIV individuals before therapy (p
KW - Alpha rhythms
KW - Delta rhythms
KW - Human immunodeficiency virus (HIV)
KW - Low-resolution brain electromagnetic source tomography (LORETA)
KW - Resting-state electroencephalography (EEG)
KW - z-Score
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U2 - 10.1016/j.nicl.2016.06.005
DO - 10.1016/j.nicl.2016.06.005
M3 - Article
AN - SCOPUS:84976873433
VL - 12
SP - 144
EP - 156
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
SN - 2213-1582
ER -