Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naïve HIV individuals

Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Susanna Lopez, Ketura Berry, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Andrea Soricelli, Elisabetta Teti, Magdalena Viscione, Cristina Limatola, Paolo OnoratiPaolo Capotosto, M. Andreoni

Research output: Contribution to journalArticle

Abstract

Objective Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. Methods Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual. They also included beta1 (13–20 Hz) and beta2 (20–30 Hz). Low-resolution brain electromagnetic tomography (LORETA) estimated EEG cortical source activity in frontal, central, temporal, parietal, and occipital regions. Results Before the therapy, the HIV group showed greater parietal delta source activity and lower spatially diffuse alpha source activity compared to the control group. Thus, the ratio of parietal delta and alpha3 source activity served as an EEG marker. The z-score showed a statistically deviant EEG marker (EEG +) in 50% of the HIV individuals before therapy (p

Original languageEnglish
Pages (from-to)144-156
Number of pages13
JournalNeuroImage: Clinical
Volume12
DOIs
Publication statusPublished - 2016

Fingerprint

HIV
Occipital Lobe
Control Groups
Parietal Lobe
Electromagnetic Phenomena
Temporal Lobe
Therapeutics
Group Psychotherapy
Healthy Volunteers
Tomography
Brain

Keywords

  • Alpha rhythms
  • Delta rhythms
  • Human immunodeficiency virus (HIV)
  • Low-resolution brain electromagnetic source tomography (LORETA)
  • Resting-state electroencephalography (EEG)
  • z-Score

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Cognitive Neuroscience
  • Neurology

Cite this

Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naïve HIV individuals. / Babiloni, Claudio; Pennica, Alfredo; Del Percio, Claudio; Noce, Giuseppe; Cordone, Susanna; Lopez, Susanna; Berry, Ketura; Muratori, Chiara; Ferracuti, Stefano; Roma, Paolo; Correr, Valentina; Di Campli, Francesco; Gianserra, Laura; Ciullini, Lorenzo; Aceti, Antonio; Soricelli, Andrea; Teti, Elisabetta; Viscione, Magdalena; Limatola, Cristina; Onorati, Paolo; Capotosto, Paolo; Andreoni, M.

In: NeuroImage: Clinical, Vol. 12, 2016, p. 144-156.

Research output: Contribution to journalArticle

Babiloni, C, Pennica, A, Del Percio, C, Noce, G, Cordone, S, Lopez, S, Berry, K, Muratori, C, Ferracuti, S, Roma, P, Correr, V, Di Campli, F, Gianserra, L, Ciullini, L, Aceti, A, Soricelli, A, Teti, E, Viscione, M, Limatola, C, Onorati, P, Capotosto, P & Andreoni, M 2016, 'Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naïve HIV individuals', NeuroImage: Clinical, vol. 12, pp. 144-156. https://doi.org/10.1016/j.nicl.2016.06.005
Babiloni, Claudio ; Pennica, Alfredo ; Del Percio, Claudio ; Noce, Giuseppe ; Cordone, Susanna ; Lopez, Susanna ; Berry, Ketura ; Muratori, Chiara ; Ferracuti, Stefano ; Roma, Paolo ; Correr, Valentina ; Di Campli, Francesco ; Gianserra, Laura ; Ciullini, Lorenzo ; Aceti, Antonio ; Soricelli, Andrea ; Teti, Elisabetta ; Viscione, Magdalena ; Limatola, Cristina ; Onorati, Paolo ; Capotosto, Paolo ; Andreoni, M. / Antiretroviral therapy affects the z-score index of deviant cortical EEG rhythms in naïve HIV individuals. In: NeuroImage: Clinical. 2016 ; Vol. 12. pp. 144-156.
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AU - Pennica, Alfredo

AU - Del Percio, Claudio

AU - Noce, Giuseppe

AU - Cordone, Susanna

AU - Lopez, Susanna

AU - Berry, Ketura

AU - Muratori, Chiara

AU - Ferracuti, Stefano

AU - Roma, Paolo

AU - Correr, Valentina

AU - Di Campli, Francesco

AU - Gianserra, Laura

AU - Ciullini, Lorenzo

AU - Aceti, Antonio

AU - Soricelli, Andrea

AU - Teti, Elisabetta

AU - Viscione, Magdalena

AU - Limatola, Cristina

AU - Onorati, Paolo

AU - Capotosto, Paolo

AU - Andreoni, M.

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N2 - Objective Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. Methods Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual. They also included beta1 (13–20 Hz) and beta2 (20–30 Hz). Low-resolution brain electromagnetic tomography (LORETA) estimated EEG cortical source activity in frontal, central, temporal, parietal, and occipital regions. Results Before the therapy, the HIV group showed greater parietal delta source activity and lower spatially diffuse alpha source activity compared to the control group. Thus, the ratio of parietal delta and alpha3 source activity served as an EEG marker. The z-score showed a statistically deviant EEG marker (EEG +) in 50% of the HIV individuals before therapy (p

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