Antiretroviral therapy and bone mineral measurements in HIV-infected youths

Gianvincenzo Zuccotti, Alessandra Viganò, Clara Gabiano, Vania Giacomet, Federica Mignone, Sara Stucchi, Valeria Manfredini, Francesca Marinacci, Stefano Mora

Research output: Contribution to journalArticle

Abstract

Reduced bone mass measurements are often found in HIV-infected youths. Both in vitro and human studies demonstrated a role of antiretroviral treatment in determining bone mass alteration. Nevertheless, the data regarding the responsibility of different antiretroviral drugs on bone health in children and adolescents are highly controversial. The purpose of the current study was to relate antiretroviral treatment to bone mass measurements in a large cohort of HIV-infected children and adolescents. Bone mineral content (BMC) was measured in 86 HIV-infected youths (aged 4.8-22.1. years), and in 194 healthy controls (aged 4.9-21.9. years). Fifteen patients were naive to antiretroviral treatment, 11 were receiving a dual nucleoside reverse transcriptase inhibitor (NRTIs) combination, 32 a protease inhibitor (PI)-based antiretroviral treatment, and 28 a non-nucleoside reverse transcriptase inhibitor (NNRTIs)-based regimen. Comparisons between healthy and HIV-infected children and adolescents have been performed by multiple regression analyses to correct for differences in age, sex, and anthropometric measurements. Patients receiving a PI-based treatment had lumbar spine and whole body BMC values significantly lower than healthy children (P

Original languageEnglish
Pages (from-to)1633-1638
Number of pages6
JournalBone
Volume46
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Antiretroviral treatment
  • Bone mineral content
  • Children
  • Dual-energy X-ray absorptiometry
  • HIV infection

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

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  • Cite this

    Zuccotti, G., Viganò, A., Gabiano, C., Giacomet, V., Mignone, F., Stucchi, S., Manfredini, V., Marinacci, F., & Mora, S. (2010). Antiretroviral therapy and bone mineral measurements in HIV-infected youths. Bone, 46(6), 1633-1638. https://doi.org/10.1016/j.bone.2010.02.029