Abstract
Treatment with antiretroviral agents (ARVs) during pregnancy is important to prevent mother-to-child transmission of the human immunodeficiency virus (HIV), but their use has been associated with low bone mineral density in adult patients. Currently, there are no data regarding the bone status of HIV-infected women who received ARV during pregnancy. The aim of this study was to evaluate cortical bone status at delivery in a group of HIV-infected women who received ARV during pregnancy and to monitor the changes occurring during the first year postpartum. We studied 33 HIV-infected and 116 HIV-uninfected healthy Caucasian women within 4 days from delivery. Follow-up measurements were performed at 4 and 12 months postpartum in 17 HIV-infected and 55 healthy women. Cortical bone status was evaluated by quantitative ultrasonography at the mid-tibia, and bone measurements were expressed as the speed of sound (SOS). HIV-infected women after delivery had a median SOS of 3,985 (3,567-4,242) m/s, while the median SOS of healthy women was 4,025 (3,643-4,250) m/s. The difference was not significant (t = 0.39, P = 0.69). No significant differences were observed between ARV-exposed and control subjects at 4 and 12 months. Our data suggest that ARV during pregnancy and the first year after delivery does not affect negatively cortical bone status.
| Original language | English |
|---|---|
| Pages (from-to) | 394-398 |
| Number of pages | 5 |
| Journal | Calcified Tissue International |
| Volume | 92 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2013 |
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Keywords
- Antiretroviral therapy
- Bone mass
- HIV infection
- Pregnancy
- Quantitative ultrasonography
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Antiretroviral therapy and pregnancy : Effect on cortical bone status of human immunodeficiency virus-infected caucasian women as assessed by quantitative ultrasonography. / Mora, Stefano; Diceglie, Cecilia; Viganò, Alessandra; Giacomet, Vania; Manfredini, Valeria; Stucchi, Sara; Fabiano, Valentina; Mameli, Chiara; Coletto, Sonia; Zuccotti, Gian V.
In: Calcified Tissue International, Vol. 92, No. 4, 04.2013, p. 394-398.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiretroviral therapy and pregnancy
T2 - Effect on cortical bone status of human immunodeficiency virus-infected caucasian women as assessed by quantitative ultrasonography
AU - Mora, Stefano
AU - Diceglie, Cecilia
AU - Viganò, Alessandra
AU - Giacomet, Vania
AU - Manfredini, Valeria
AU - Stucchi, Sara
AU - Fabiano, Valentina
AU - Mameli, Chiara
AU - Coletto, Sonia
AU - Zuccotti, Gian V.
PY - 2013/4
Y1 - 2013/4
N2 - Treatment with antiretroviral agents (ARVs) during pregnancy is important to prevent mother-to-child transmission of the human immunodeficiency virus (HIV), but their use has been associated with low bone mineral density in adult patients. Currently, there are no data regarding the bone status of HIV-infected women who received ARV during pregnancy. The aim of this study was to evaluate cortical bone status at delivery in a group of HIV-infected women who received ARV during pregnancy and to monitor the changes occurring during the first year postpartum. We studied 33 HIV-infected and 116 HIV-uninfected healthy Caucasian women within 4 days from delivery. Follow-up measurements were performed at 4 and 12 months postpartum in 17 HIV-infected and 55 healthy women. Cortical bone status was evaluated by quantitative ultrasonography at the mid-tibia, and bone measurements were expressed as the speed of sound (SOS). HIV-infected women after delivery had a median SOS of 3,985 (3,567-4,242) m/s, while the median SOS of healthy women was 4,025 (3,643-4,250) m/s. The difference was not significant (t = 0.39, P = 0.69). No significant differences were observed between ARV-exposed and control subjects at 4 and 12 months. Our data suggest that ARV during pregnancy and the first year after delivery does not affect negatively cortical bone status.
AB - Treatment with antiretroviral agents (ARVs) during pregnancy is important to prevent mother-to-child transmission of the human immunodeficiency virus (HIV), but their use has been associated with low bone mineral density in adult patients. Currently, there are no data regarding the bone status of HIV-infected women who received ARV during pregnancy. The aim of this study was to evaluate cortical bone status at delivery in a group of HIV-infected women who received ARV during pregnancy and to monitor the changes occurring during the first year postpartum. We studied 33 HIV-infected and 116 HIV-uninfected healthy Caucasian women within 4 days from delivery. Follow-up measurements were performed at 4 and 12 months postpartum in 17 HIV-infected and 55 healthy women. Cortical bone status was evaluated by quantitative ultrasonography at the mid-tibia, and bone measurements were expressed as the speed of sound (SOS). HIV-infected women after delivery had a median SOS of 3,985 (3,567-4,242) m/s, while the median SOS of healthy women was 4,025 (3,643-4,250) m/s. The difference was not significant (t = 0.39, P = 0.69). No significant differences were observed between ARV-exposed and control subjects at 4 and 12 months. Our data suggest that ARV during pregnancy and the first year after delivery does not affect negatively cortical bone status.
KW - Antiretroviral therapy
KW - Bone mass
KW - HIV infection
KW - Pregnancy
KW - Quantitative ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=84876667572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876667572&partnerID=8YFLogxK
U2 - 10.1007/s00223-013-9696-8
DO - 10.1007/s00223-013-9696-8
M3 - Article
C2 - 23307187
AN - SCOPUS:84876667572
VL - 92
SP - 394
EP - 398
JO - Calcified Tissue International
JF - Calcified Tissue International
SN - 0171-967X
IS - 4
ER -