Antiretroviral therapy effects on sources of cortical rhythms in HIV subjects: Responders vs. Mild Responders

Claudio Babiloni, Alfredo Pennica, Fabrizio Vecchio, Paolo Onorati, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Nicole Donato, Giuseppe Noce, Claudio Del Percio, Cristiano Bonacci, Francesco Di Campli, Laura Gianserra, Elisabetta Teti, Antonio Aceti, Andrea Soricelli, Magdalena Viscione, Paolo M. Rossini, Massimo Andreoni

Research output: Contribution to journalArticlepeer-review


Objective: We tested the hypothesis that 5. months of combined anti-retroviral therapy (cART) affect cortical sources of resting state cortical electroencephalographic (EEG) rhythms in naïve HIV subjects. Methods: Eyes-closed resting state EEG data were recorded at baseline (i.e. pre-treatment; T0), T1 (after 4. weeks of cART), T2 (after 8. weeks of cART), and T5 (after 5. months of cART) in 38 naïve HIV subjects. EEG data were also recorded in 40 age-matched cognitively normal subjects for control purposes. EEG rhythms of interest were delta (2-4. Hz), theta (4-8. Hz), alpha 1 (8-10.5. Hz), alpha 2 (10.5-13. Hz), beta 1 (13-20. Hz), and beta 2 (20-30. Hz). Cortical EEG sources were estimated by LORETA software. Results: Compared to the control group, the HIV group at T0 showed greater delta sources and lower widespread alpha sources. cART induced a global improvement of biological (viral load, CD4 count) and EEG (delta, alpha) markers, remarkable even after 4. weeks. Compared to HIV Responders (>100. cells/μl at 5-month follow up), the HIV Mild Responders (

Original languageEnglish
Pages (from-to)68-81
Number of pages14
JournalClinical Neurophysiology
Issue number1
Publication statusPublished - Jan 1 2015


  • Alpha
  • Brain rhythms
  • CD4 lymphocyte
  • Human immunodeficiency virus (HIV)
  • Low-resolution brain electromagnetic source tomography (LORETA)
  • Resting-state electroencephalography (EEG)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems
  • Medicine(all)


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