Gli antisecretivi nell'emorragia del tratto gastroenterico superiore

Translated title of the contribution: Antisecretory therapy for upper gastrointestinal bleeding

Valentine Casini, Elisa Ferrara, Marco Lazzaroni, Gabriele Bianchi Porro

Research output: Contribution to journalArticle

Abstract

Aim of the paper was to review what is known about the effectiveness of antisecretory therapy for acute upper gastrointestinal bleeding. Upper gastrointestinal endoscopy has become the standard of care in such cases, as it reliably establishes the etiology of bleeding and allows for active hemostatic therapy for any lesion identified. Although endoscopic hemostasis is successful in more than 90% of cases of bleeding peptic ulcer, rebleeding occurs within 72 hr in up to 25% of cases such that rebleeding following successful hemostasis has become the major unsolved problem in the management of acute upper gastrointestinal bleeding. The available data are consistent with the notion that reliable maintenance of the intragastric pH at ≥ 6 after endoscopic hemostasis is associated with the lowest rebleeding rates. H 2- receptor antagonists are scarcely effective for achieving this goal.

Original languageItalian
Pages (from-to)29-39
Number of pages11
JournalArgomenti di Gastroenterologia Clinica
Volume18
Issue number3
Publication statusPublished - Dec 2005

Fingerprint

Endoscopic Hemostasis
Hemorrhage
Gastrointestinal Endoscopy
Hemostatics
Therapeutics
Standard of Care
Hemostasis
Peptic Ulcer
Maintenance

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gli antisecretivi nell'emorragia del tratto gastroenterico superiore. / Casini, Valentine; Ferrara, Elisa; Lazzaroni, Marco; Porro, Gabriele Bianchi.

In: Argomenti di Gastroenterologia Clinica, Vol. 18, No. 3, 12.2005, p. 29-39.

Research output: Contribution to journalArticle

Casini, Valentine ; Ferrara, Elisa ; Lazzaroni, Marco ; Porro, Gabriele Bianchi. / Gli antisecretivi nell'emorragia del tratto gastroenterico superiore. In: Argomenti di Gastroenterologia Clinica. 2005 ; Vol. 18, No. 3. pp. 29-39.
@article{282a1a84116e40dcbadb2167aa01c759,
title = "Gli antisecretivi nell'emorragia del tratto gastroenterico superiore",
abstract = "Aim of the paper was to review what is known about the effectiveness of antisecretory therapy for acute upper gastrointestinal bleeding. Upper gastrointestinal endoscopy has become the standard of care in such cases, as it reliably establishes the etiology of bleeding and allows for active hemostatic therapy for any lesion identified. Although endoscopic hemostasis is successful in more than 90{\%} of cases of bleeding peptic ulcer, rebleeding occurs within 72 hr in up to 25{\%} of cases such that rebleeding following successful hemostasis has become the major unsolved problem in the management of acute upper gastrointestinal bleeding. The available data are consistent with the notion that reliable maintenance of the intragastric pH at ≥ 6 after endoscopic hemostasis is associated with the lowest rebleeding rates. H 2- receptor antagonists are scarcely effective for achieving this goal.",
keywords = "Antisecretory therapy, H - receptor antagonists, Peptic ulcer, Proton pump inhibitors, Upper gastrointestinal bleeding",
author = "Valentine Casini and Elisa Ferrara and Marco Lazzaroni and Porro, {Gabriele Bianchi}",
year = "2005",
month = "12",
language = "Italian",
volume = "18",
pages = "29--39",
journal = "Argomenti di Gastroenterologia Clinica",
issn = "1120-8651",
publisher = "Masson SpA",
number = "3",

}

TY - JOUR

T1 - Gli antisecretivi nell'emorragia del tratto gastroenterico superiore

AU - Casini, Valentine

AU - Ferrara, Elisa

AU - Lazzaroni, Marco

AU - Porro, Gabriele Bianchi

PY - 2005/12

Y1 - 2005/12

N2 - Aim of the paper was to review what is known about the effectiveness of antisecretory therapy for acute upper gastrointestinal bleeding. Upper gastrointestinal endoscopy has become the standard of care in such cases, as it reliably establishes the etiology of bleeding and allows for active hemostatic therapy for any lesion identified. Although endoscopic hemostasis is successful in more than 90% of cases of bleeding peptic ulcer, rebleeding occurs within 72 hr in up to 25% of cases such that rebleeding following successful hemostasis has become the major unsolved problem in the management of acute upper gastrointestinal bleeding. The available data are consistent with the notion that reliable maintenance of the intragastric pH at ≥ 6 after endoscopic hemostasis is associated with the lowest rebleeding rates. H 2- receptor antagonists are scarcely effective for achieving this goal.

AB - Aim of the paper was to review what is known about the effectiveness of antisecretory therapy for acute upper gastrointestinal bleeding. Upper gastrointestinal endoscopy has become the standard of care in such cases, as it reliably establishes the etiology of bleeding and allows for active hemostatic therapy for any lesion identified. Although endoscopic hemostasis is successful in more than 90% of cases of bleeding peptic ulcer, rebleeding occurs within 72 hr in up to 25% of cases such that rebleeding following successful hemostasis has become the major unsolved problem in the management of acute upper gastrointestinal bleeding. The available data are consistent with the notion that reliable maintenance of the intragastric pH at ≥ 6 after endoscopic hemostasis is associated with the lowest rebleeding rates. H 2- receptor antagonists are scarcely effective for achieving this goal.

KW - Antisecretory therapy

KW - H - receptor antagonists

KW - Peptic ulcer

KW - Proton pump inhibitors

KW - Upper gastrointestinal bleeding

UR - http://www.scopus.com/inward/record.url?scp=30644468360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30644468360&partnerID=8YFLogxK

M3 - Articolo

AN - SCOPUS:30644468360

VL - 18

SP - 29

EP - 39

JO - Argomenti di Gastroenterologia Clinica

JF - Argomenti di Gastroenterologia Clinica

SN - 1120-8651

IS - 3

ER -