Abstract
Aim of the paper was to review what is known about the effectiveness of antisecretory therapy for acute upper gastrointestinal bleeding. Upper gastrointestinal endoscopy has become the standard of care in such cases, as it reliably establishes the etiology of bleeding and allows for active hemostatic therapy for any lesion identified. Although endoscopic hemostasis is successful in more than 90% of cases of bleeding peptic ulcer, rebleeding occurs within 72 hr in up to 25% of cases such that rebleeding following successful hemostasis has become the major unsolved problem in the management of acute upper gastrointestinal bleeding. The available data are consistent with the notion that reliable maintenance of the intragastric pH at ≥ 6 after endoscopic hemostasis is associated with the lowest rebleeding rates. H 2- receptor antagonists are scarcely effective for achieving this goal.
| Original language | Italian |
|---|---|
| Pages (from-to) | 29-39 |
| Number of pages | 11 |
| Journal | Argomenti di Gastroenterologia Clinica |
| Volume | 18 |
| Issue number | 3 |
| Publication status | Published - Dec 2005 |
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ASJC Scopus subject areas
- Gastroenterology
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Gli antisecretivi nell'emorragia del tratto gastroenterico superiore. / Casini, Valentine; Ferrara, Elisa; Lazzaroni, Marco; Porro, Gabriele Bianchi.
In: Argomenti di Gastroenterologia Clinica, Vol. 18, No. 3, 12.2005, p. 29-39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gli antisecretivi nell'emorragia del tratto gastroenterico superiore
AU - Casini, Valentine
AU - Ferrara, Elisa
AU - Lazzaroni, Marco
AU - Porro, Gabriele Bianchi
PY - 2005/12
Y1 - 2005/12
N2 - Aim of the paper was to review what is known about the effectiveness of antisecretory therapy for acute upper gastrointestinal bleeding. Upper gastrointestinal endoscopy has become the standard of care in such cases, as it reliably establishes the etiology of bleeding and allows for active hemostatic therapy for any lesion identified. Although endoscopic hemostasis is successful in more than 90% of cases of bleeding peptic ulcer, rebleeding occurs within 72 hr in up to 25% of cases such that rebleeding following successful hemostasis has become the major unsolved problem in the management of acute upper gastrointestinal bleeding. The available data are consistent with the notion that reliable maintenance of the intragastric pH at ≥ 6 after endoscopic hemostasis is associated with the lowest rebleeding rates. H 2- receptor antagonists are scarcely effective for achieving this goal.
AB - Aim of the paper was to review what is known about the effectiveness of antisecretory therapy for acute upper gastrointestinal bleeding. Upper gastrointestinal endoscopy has become the standard of care in such cases, as it reliably establishes the etiology of bleeding and allows for active hemostatic therapy for any lesion identified. Although endoscopic hemostasis is successful in more than 90% of cases of bleeding peptic ulcer, rebleeding occurs within 72 hr in up to 25% of cases such that rebleeding following successful hemostasis has become the major unsolved problem in the management of acute upper gastrointestinal bleeding. The available data are consistent with the notion that reliable maintenance of the intragastric pH at ≥ 6 after endoscopic hemostasis is associated with the lowest rebleeding rates. H 2- receptor antagonists are scarcely effective for achieving this goal.
KW - Antisecretory therapy
KW - H - receptor antagonists
KW - Peptic ulcer
KW - Proton pump inhibitors
KW - Upper gastrointestinal bleeding
UR - http://www.scopus.com/inward/record.url?scp=30644468360&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30644468360&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:30644468360
VL - 18
SP - 29
EP - 39
JO - Argomenti di Gastroenterologia Clinica
JF - Argomenti di Gastroenterologia Clinica
SN - 1120-8651
IS - 3
ER -