Antiserotonin treatment of hyperprolactinemic amenorrhea: Long-term follow-up with metergoline, methysergide, and cyproheptadine

Pier Giorgio Crosignani, Maddalena Peracchi, Gian Carlo Lombroso, Eugenio Reschini, Anna Mattei, Anna Caccamo, Alberto D'Alberton

Research output: Contribution to journalArticle

Abstract

Twenty patients affected by hyperprolactinemic amenorrhea-galactorrhea have been treated with one or more of the following serotonin antagonists: metergoline, methysergide, and cyproheptadine. Among the 11 patients without evidence of pituitary tumor resumption of menses was observed in five, two of whom had ovulatory cycles; one patient became pregnant; ovulations occurred only during treatment with metergoline. In the group of nine patients with enlarged sellae, three experienced isolated episodes of bleeding, while two had three and four menses each, respectively; all cycles were anovulatory. Plasma prolactin levels and galactorrhea were favorably affected by treatment only in a minority of amenorrhea-galactorrhea patients with and without tumors.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume132
Issue number3
Publication statusPublished - Oct 1 1978

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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    Crosignani, P. G., Peracchi, M., Lombroso, G. C., Reschini, E., Mattei, A., Caccamo, A., & D'Alberton, A. (1978). Antiserotonin treatment of hyperprolactinemic amenorrhea: Long-term follow-up with metergoline, methysergide, and cyproheptadine. American Journal of Obstetrics and Gynecology, 132(3), 307-312.