Antithrombin plasma levels decrease is associated with preeclampsia worsening

M. Marietta, L. Simoni, P. Pedrazzi, L. Facchini, R. D'Amico, F. Facchinetti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Antithrombin plasma levels (AT) have been found decreased in women with preeclampsia (PE), but little is known about the trend of AT during the course of this disease. We prospectively investigated AT in consecutive women admitted to our hospital with a diagnosis of PE, to assess if AT fluctuations could be associated with the evolution of the disease. AT, platelet count and d-dimer levels were determined every other day. In the 73 patients studied, AT, platelet count and fibrinogen progressively reduced during the observational period, reaching a nadir on the day of delivery, whereas d-dimer progressively increased over time. Statistical analysis was restricted to the 39 women that had an AT measurement performed on each of days -1, 0 and +1, with respect to the day of delivery. These subjects showed a significant decrease in AT on the day of delivery compared to the day just before (77.8 ± 15.1%vs. 85.4 ± 14.2%, P = 0.027), followed by a recovery on the first day after delivery (87.6 ± 21.3% from 77.8 ± 15.1%, P = 0.005). Our study demonstrates that a significant drop in AT levels is associated with the clinical worsening of PE, regardless of its severity.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalInternational Journal of Laboratory Hematology
Volume31
Issue number2
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Antithrombins
Platelets
Pre-Eclampsia
Dimers
Platelet Count
Plasmas
Fibrinogen
Statistical methods
Recovery

Keywords

  • Antithrombin
  • D-dimer
  • HELLP syndrome
  • Platelet count
  • Preeclampsia
  • Pregnancy complications

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Hematology

Cite this

Antithrombin plasma levels decrease is associated with preeclampsia worsening. / Marietta, M.; Simoni, L.; Pedrazzi, P.; Facchini, L.; D'Amico, R.; Facchinetti, F.

In: International Journal of Laboratory Hematology, Vol. 31, No. 2, 04.2009, p. 227-232.

Research output: Contribution to journalArticle

Marietta, M. ; Simoni, L. ; Pedrazzi, P. ; Facchini, L. ; D'Amico, R. ; Facchinetti, F. / Antithrombin plasma levels decrease is associated with preeclampsia worsening. In: International Journal of Laboratory Hematology. 2009 ; Vol. 31, No. 2. pp. 227-232.
@article{5746a2ba68f44e9d92c8402cd9c511ec,
title = "Antithrombin plasma levels decrease is associated with preeclampsia worsening",
abstract = "Antithrombin plasma levels (AT) have been found decreased in women with preeclampsia (PE), but little is known about the trend of AT during the course of this disease. We prospectively investigated AT in consecutive women admitted to our hospital with a diagnosis of PE, to assess if AT fluctuations could be associated with the evolution of the disease. AT, platelet count and d-dimer levels were determined every other day. In the 73 patients studied, AT, platelet count and fibrinogen progressively reduced during the observational period, reaching a nadir on the day of delivery, whereas d-dimer progressively increased over time. Statistical analysis was restricted to the 39 women that had an AT measurement performed on each of days -1, 0 and +1, with respect to the day of delivery. These subjects showed a significant decrease in AT on the day of delivery compared to the day just before (77.8 ± 15.1{\%}vs. 85.4 ± 14.2{\%}, P = 0.027), followed by a recovery on the first day after delivery (87.6 ± 21.3{\%} from 77.8 ± 15.1{\%}, P = 0.005). Our study demonstrates that a significant drop in AT levels is associated with the clinical worsening of PE, regardless of its severity.",
keywords = "Antithrombin, D-dimer, HELLP syndrome, Platelet count, Preeclampsia, Pregnancy complications",
author = "M. Marietta and L. Simoni and P. Pedrazzi and L. Facchini and R. D'Amico and F. Facchinetti",
year = "2009",
month = "4",
doi = "10.1111/j.1751-553X.2008.01031.x",
language = "English",
volume = "31",
pages = "227--232",
journal = "International Journal of Laboratory Hematology",
issn = "1751-5521",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Antithrombin plasma levels decrease is associated with preeclampsia worsening

AU - Marietta, M.

AU - Simoni, L.

AU - Pedrazzi, P.

AU - Facchini, L.

AU - D'Amico, R.

AU - Facchinetti, F.

PY - 2009/4

Y1 - 2009/4

N2 - Antithrombin plasma levels (AT) have been found decreased in women with preeclampsia (PE), but little is known about the trend of AT during the course of this disease. We prospectively investigated AT in consecutive women admitted to our hospital with a diagnosis of PE, to assess if AT fluctuations could be associated with the evolution of the disease. AT, platelet count and d-dimer levels were determined every other day. In the 73 patients studied, AT, platelet count and fibrinogen progressively reduced during the observational period, reaching a nadir on the day of delivery, whereas d-dimer progressively increased over time. Statistical analysis was restricted to the 39 women that had an AT measurement performed on each of days -1, 0 and +1, with respect to the day of delivery. These subjects showed a significant decrease in AT on the day of delivery compared to the day just before (77.8 ± 15.1%vs. 85.4 ± 14.2%, P = 0.027), followed by a recovery on the first day after delivery (87.6 ± 21.3% from 77.8 ± 15.1%, P = 0.005). Our study demonstrates that a significant drop in AT levels is associated with the clinical worsening of PE, regardless of its severity.

AB - Antithrombin plasma levels (AT) have been found decreased in women with preeclampsia (PE), but little is known about the trend of AT during the course of this disease. We prospectively investigated AT in consecutive women admitted to our hospital with a diagnosis of PE, to assess if AT fluctuations could be associated with the evolution of the disease. AT, platelet count and d-dimer levels were determined every other day. In the 73 patients studied, AT, platelet count and fibrinogen progressively reduced during the observational period, reaching a nadir on the day of delivery, whereas d-dimer progressively increased over time. Statistical analysis was restricted to the 39 women that had an AT measurement performed on each of days -1, 0 and +1, with respect to the day of delivery. These subjects showed a significant decrease in AT on the day of delivery compared to the day just before (77.8 ± 15.1%vs. 85.4 ± 14.2%, P = 0.027), followed by a recovery on the first day after delivery (87.6 ± 21.3% from 77.8 ± 15.1%, P = 0.005). Our study demonstrates that a significant drop in AT levels is associated with the clinical worsening of PE, regardless of its severity.

KW - Antithrombin

KW - D-dimer

KW - HELLP syndrome

KW - Platelet count

KW - Preeclampsia

KW - Pregnancy complications

UR - http://www.scopus.com/inward/record.url?scp=61349111551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61349111551&partnerID=8YFLogxK

U2 - 10.1111/j.1751-553X.2008.01031.x

DO - 10.1111/j.1751-553X.2008.01031.x

M3 - Article

C2 - 18284416

AN - SCOPUS:61349111551

VL - 31

SP - 227

EP - 232

JO - International Journal of Laboratory Hematology

JF - International Journal of Laboratory Hematology

SN - 1751-5521

IS - 2

ER -