Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency

Andrea Artoni, Serena Maria Passamonti, Alberto Edefonti, Francesca Gianniello, Vittorio Civelli, Ida Martinelli

Research output: Contribution to journalArticlepeer-review


Background: Nephrotic syndrome confers an acquired prothrombotic phenotype due to the urinary loss of anticoagulant proteins.Patients with reactivation of nephrotic syndrome may develop thrombosis. Case presentation: We report the case of a life-threatening cerebral venous thrombosis in a 13 year-old boy affected by a relapse of nephrotic syndrome during a P. aeruginosa otitis/mastoiditis. Due to the worsening general conditions and the severe neurological impairment, a course of systemic thrombolysis was successfully administered, followed by anticoagulant therapy. In the present case severe inherited thrombophilia (inherited dysfunctional protein S deficiency) was identified as an important additional risk factors for thrombosis. Conclusions: A careful evalutaion of risk factos for thrombosi during reactivation of nephrotic syndrome include measurement of plasma anticaogulant proteins. When low, antithrombotic prophylaxis with heparin should be considered to prevent thrombotic episodes.

Original languageEnglish
Article number22
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - Feb 29 2016


  • Cerebral vein thrombosis
  • Nephrotic syndrome
  • Pediatric
  • Thrombolysis
  • Thrombophilia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency'. Together they form a unique fingerprint.

Cite this