Antitumoral activity of human fibroblast interferon administered intranodularly

Riccardo Rosso, Maria Teresa Nobile, Mario Roberto Sertoli, Aldo Giannitelli, Pier Luigi Santi, Rachele Volpe, Guido Nicol Ò

Research output: Contribution to journalArticle


Human fibroblast interferon was given intranodularly to 14 patients with cutaneous metastases from breast cancer and malignant melanoma; 1,000,000 units/cm3 of tumor tissue was administered daily for 8-10 days. 13 patients were evaluated. Complete response was achieved in 1 of 7 breast carcinoma nodules and in 2 of 6 melanoma nodules; partial response was achieved in 1 of 7 breast carcinoma and in 3 of 6 melanoma nodules. The overall objective response was therefore 7 of 13 (53.8%) metastatic nodules. Pathological complete response was confirmed in 2 of 3 complete clinical responses. Necrosis, lymphocytic infiltration and fibrosis were observed in all the specimens pathologically examined. In spite of a clear antitumoral activity, this approach does not appear to have clinical significance due to its extremely localized effect.

Original languageEnglish
Pages (from-to)86-88
Number of pages3
Issue number2
Publication statusPublished - 1985


  • Breast cancer
  • Fibroblast interferon
  • Intranodular administration
  • Melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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