Antitumoral activity of human fibroblast interferon administered intranodularly

Riccardo Rosso, Maria Teresa Nobile, Mario Roberto Sertoli, Aldo Giannitelli, Pier Luigi Santi, Rachele Volpe, Guido Nicol Ò

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Human fibroblast interferon was given intranodularly to 14 patients with cutaneous metastases from breast cancer and malignant melanoma; 1,000,000 units/cm3 of tumor tissue was administered daily for 8-10 days. 13 patients were evaluated. Complete response was achieved in 1 of 7 breast carcinoma nodules and in 2 of 6 melanoma nodules; partial response was achieved in 1 of 7 breast carcinoma and in 3 of 6 melanoma nodules. The overall objective response was therefore 7 of 13 (53.8%) metastatic nodules. Pathological complete response was confirmed in 2 of 3 complete clinical responses. Necrosis, lymphocytic infiltration and fibrosis were observed in all the specimens pathologically examined. In spite of a clear antitumoral activity, this approach does not appear to have clinical significance due to its extremely localized effect.

Original languageEnglish
Pages (from-to)86-88
Number of pages3
JournalOncology
Volume42
Issue number2
DOIs
Publication statusPublished - 1985

Fingerprint

Interferon-beta
Human Activities
Melanoma
Breast Neoplasms
Fibrosis
Necrosis
Neoplasm Metastasis
Skin
Neoplasms

Keywords

  • Breast cancer
  • Fibroblast interferon
  • Intranodular administration
  • Melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rosso, R., Nobile, M. T., Sertoli, M. R., Giannitelli, A., Santi, P. L., Volpe, R., & Nicol Ò, G. (1985). Antitumoral activity of human fibroblast interferon administered intranodularly. Oncology, 42(2), 86-88. https://doi.org/10.1159/000226006

Antitumoral activity of human fibroblast interferon administered intranodularly. / Rosso, Riccardo; Nobile, Maria Teresa; Sertoli, Mario Roberto; Giannitelli, Aldo; Santi, Pier Luigi; Volpe, Rachele; Nicol Ò, Guido.

In: Oncology, Vol. 42, No. 2, 1985, p. 86-88.

Research output: Contribution to journalArticle

Rosso, R, Nobile, MT, Sertoli, MR, Giannitelli, A, Santi, PL, Volpe, R & Nicol Ò, G 1985, 'Antitumoral activity of human fibroblast interferon administered intranodularly', Oncology, vol. 42, no. 2, pp. 86-88. https://doi.org/10.1159/000226006
Rosso R, Nobile MT, Sertoli MR, Giannitelli A, Santi PL, Volpe R et al. Antitumoral activity of human fibroblast interferon administered intranodularly. Oncology. 1985;42(2):86-88. https://doi.org/10.1159/000226006
Rosso, Riccardo ; Nobile, Maria Teresa ; Sertoli, Mario Roberto ; Giannitelli, Aldo ; Santi, Pier Luigi ; Volpe, Rachele ; Nicol Ò, Guido. / Antitumoral activity of human fibroblast interferon administered intranodularly. In: Oncology. 1985 ; Vol. 42, No. 2. pp. 86-88.
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