Antitumorigenic effect of dietary natural compounds via lipid metabolism modulation in ApcMin/+ Mice

Maria Notarnicola, Valeria Tutino, Angela Tafaro, Francesca Amatulli, Maria Gabriella Caruso

Research output: Contribution to journalArticle

Abstract

Aim: The aim of the present study was to evaluate the effects of a diet supplementation with either olive oil, or n-3 or n-6-polyunsaturatedFatty acids (PUFAs) on tumour development and gene expression for lipogenic enzymes in ApcMin/+ mice. Materials and Methods: In the control group, the mice received a standard diet, the OO group was fed on a diet with 12% olive oil, the OM-3 group with 12% salmon fish rich in n-3 PUFAs, the OM-6 group with 12% oenothera oil rich in n-6 PUFAs. Gene expression of lipogenic enzymes was evaluated by real-time reverse transcription polymerase chain reaction. Results: All mice in the treated groups presented a reduction in total intestinal polyp number and load, which was particularly marked in the OM-3 group. Treated mice showed an induction of low density lipoprotein receptor gene expression and a significant reduction of expression of lipogenic gene. Conclusion: Our data provide new insights into the mechanism of cell growth inhibition and apoptotic regulation by dietary olive oil and PUFAs in ApcMin/+ mice.

Original languageEnglish
Pages (from-to)3739-3744
Number of pages6
JournalAnticancer Research
Volume33
Issue number9
Publication statusPublished - Sep 2013

Keywords

  • Colorectal cancer
  • Gene expression
  • Lipid metabolism
  • Olive oil
  • Polyunsaturated fatty acids (PUFAs)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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