Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice

Cheryl A. Stoddart, Mary E. Moreno, Valerie D. Linquist-Stepps, Christopher Bare, Mark R. Bogan, Alberto Gobbi, Robert W. Buckheit, Jean Bedard, Robert F. Rando, Joseph M. McCune

Research output: Contribution to journalArticle

Abstract

Oral administration of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652), a nucleoside analog structurally similar to lamivudine (3TC), caused dose- dependent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency virus type 1 NL4-3 and with an NL4-3 clone containing the M184V mutation in reverse transcriptase that confers resistance to 3TC. These experiments demonstrate the utility of this mouse model for evaluating drug resistance and for performing direct comparisons between antiviral compounds in vivo.

Original languageEnglish
Pages (from-to)783-786
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number3
DOIs
Publication statusPublished - Mar 2000

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice'. Together they form a unique fingerprint.

  • Cite this

    Stoddart, C. A., Moreno, M. E., Linquist-Stepps, V. D., Bare, C., Bogan, M. R., Gobbi, A., Buckheit, R. W., Bedard, J., Rando, R. F., & McCune, J. M. (2000). Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice. Antimicrobial Agents and Chemotherapy, 44(3), 783-786. https://doi.org/10.1128/AAC.44.3.783-786.2000