Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus

M. G. Santoro, C. Favalli, A. Mastino, B. M. Jaffe, M. Esteban, E. Garaci

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously shown that prostaglandins of the A series potently inhibit virus replication in several virus-host systems in vitro. In the present report we have studied the effect of a long-acting synthetic analog of PGA, 16,16-dimethyl-PGA2 (Di-M-PGA2), on virus infection in vivo, using as a model Balb/c mice infected with influenza A (PR8) virus. Depending upon the dose of viral inoculum, PR8 virus caused the death of 50 to 100% of the animals in a period of 8-20 days. Di-M-PGA2-treatment significantly increased mouse survival by an average of 40%, independently of the dose of inoculum and the age of the animals. The fact that Di-M-PGA2-treatment decreased virus titers in the lungs and did not alter the host immune response, suggested that PGA's therapeutic action was due to suppression of virus replication. Finally, two anti-inflammatory compounds, which inhibit prostaglandin synthesis, aspirin and indomethacin, were shown not to significantly alter mouse survival in this system.

Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalArchives of Virology
Volume99
Issue number1-2
DOIs
Publication statusPublished - Mar 1988

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

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