Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report

Bruno Annibale, Margherita Bonamico, Guido Rindi, Laura Villani, Enzo Ferrante, Andrea Vania, Enrico Solcia, Gianfranco Delle Fave

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Antral gastrin cell hyperfunction is a rare condition, often associated with severe duodenal ulcer disease. In children, clinical and functional characteristics of this syndrome are poorly known. Two cases are described here: one child had melena and the other had moderate abdominal pain, both without peptic ulceration. Basal and postprandial increase of gastrin levels showed a response over the upper normal range, indicating gastrin cell hyperfunction. Acid hypersecretion, both basal and after pentagastrin stimulation, was also found in the two children, confirming the biological effect of their sustained hypergastrinemia. Gastrin cell counts were within the normal range, while the number of somatostatin D cells was significantly reduced. This report stresses the importance of diagnosing antral gastrin cell hyperfunction in children because this unrecognized condition may manifest with serious complications (bleeding) or nonspecific abdominal symptoms.

Original languageEnglish
Pages (from-to)1547-1551
Number of pages5
JournalGastroenterology
Volume101
Issue number6
Publication statusPublished - 1991

Fingerprint

Gastrin-Secreting Cells
Somatostatin-Secreting Cells
Reference Values
Duodenal Diseases
Melena
Pentagastrin
Gastrins
Duodenal Ulcer
Abdominal Pain
Digestion
Cell Count
Hemorrhage
Acids
Antral

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Annibale, B., Bonamico, M., Rindi, G., Villani, L., Ferrante, E., Vania, A., ... Delle Fave, G. (1991). Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report. Gastroenterology, 101(6), 1547-1551.

Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report. / Annibale, Bruno; Bonamico, Margherita; Rindi, Guido; Villani, Laura; Ferrante, Enzo; Vania, Andrea; Solcia, Enrico; Delle Fave, Gianfranco.

In: Gastroenterology, Vol. 101, No. 6, 1991, p. 1547-1551.

Research output: Contribution to journalArticle

Annibale, B, Bonamico, M, Rindi, G, Villani, L, Ferrante, E, Vania, A, Solcia, E & Delle Fave, G 1991, 'Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report', Gastroenterology, vol. 101, no. 6, pp. 1547-1551.
Annibale B, Bonamico M, Rindi G, Villani L, Ferrante E, Vania A et al. Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report. Gastroenterology. 1991;101(6):1547-1551.
Annibale, Bruno ; Bonamico, Margherita ; Rindi, Guido ; Villani, Laura ; Ferrante, Enzo ; Vania, Andrea ; Solcia, Enrico ; Delle Fave, Gianfranco. / Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report. In: Gastroenterology. 1991 ; Vol. 101, No. 6. pp. 1547-1551.
@article{08b025c74f424fd3a714b2e30f877694,
title = "Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report",
abstract = "Antral gastrin cell hyperfunction is a rare condition, often associated with severe duodenal ulcer disease. In children, clinical and functional characteristics of this syndrome are poorly known. Two cases are described here: one child had melena and the other had moderate abdominal pain, both without peptic ulceration. Basal and postprandial increase of gastrin levels showed a response over the upper normal range, indicating gastrin cell hyperfunction. Acid hypersecretion, both basal and after pentagastrin stimulation, was also found in the two children, confirming the biological effect of their sustained hypergastrinemia. Gastrin cell counts were within the normal range, while the number of somatostatin D cells was significantly reduced. This report stresses the importance of diagnosing antral gastrin cell hyperfunction in children because this unrecognized condition may manifest with serious complications (bleeding) or nonspecific abdominal symptoms.",
author = "Bruno Annibale and Margherita Bonamico and Guido Rindi and Laura Villani and Enzo Ferrante and Andrea Vania and Enrico Solcia and {Delle Fave}, Gianfranco",
year = "1991",
language = "English",
volume = "101",
pages = "1547--1551",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report

AU - Annibale, Bruno

AU - Bonamico, Margherita

AU - Rindi, Guido

AU - Villani, Laura

AU - Ferrante, Enzo

AU - Vania, Andrea

AU - Solcia, Enrico

AU - Delle Fave, Gianfranco

PY - 1991

Y1 - 1991

N2 - Antral gastrin cell hyperfunction is a rare condition, often associated with severe duodenal ulcer disease. In children, clinical and functional characteristics of this syndrome are poorly known. Two cases are described here: one child had melena and the other had moderate abdominal pain, both without peptic ulceration. Basal and postprandial increase of gastrin levels showed a response over the upper normal range, indicating gastrin cell hyperfunction. Acid hypersecretion, both basal and after pentagastrin stimulation, was also found in the two children, confirming the biological effect of their sustained hypergastrinemia. Gastrin cell counts were within the normal range, while the number of somatostatin D cells was significantly reduced. This report stresses the importance of diagnosing antral gastrin cell hyperfunction in children because this unrecognized condition may manifest with serious complications (bleeding) or nonspecific abdominal symptoms.

AB - Antral gastrin cell hyperfunction is a rare condition, often associated with severe duodenal ulcer disease. In children, clinical and functional characteristics of this syndrome are poorly known. Two cases are described here: one child had melena and the other had moderate abdominal pain, both without peptic ulceration. Basal and postprandial increase of gastrin levels showed a response over the upper normal range, indicating gastrin cell hyperfunction. Acid hypersecretion, both basal and after pentagastrin stimulation, was also found in the two children, confirming the biological effect of their sustained hypergastrinemia. Gastrin cell counts were within the normal range, while the number of somatostatin D cells was significantly reduced. This report stresses the importance of diagnosing antral gastrin cell hyperfunction in children because this unrecognized condition may manifest with serious complications (bleeding) or nonspecific abdominal symptoms.

UR - http://www.scopus.com/inward/record.url?scp=0025989525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025989525&partnerID=8YFLogxK

M3 - Article

C2 - 1683324

AN - SCOPUS:0025989525

VL - 101

SP - 1547

EP - 1551

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -