Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report

Bruno Annibale, Margherita Bonamico, Guido Rindi, Laura Villani, Enzo Ferrante, Andrea Vania, Enrico Solcia, Gianfranco Delle Fave

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Antral gastrin cell hyperfunction is a rare condition, often associated with severe duodenal ulcer disease. In children, clinical and functional characteristics of this syndrome are poorly known. Two cases are described here: one child had melena and the other had moderate abdominal pain, both without peptic ulceration. Basal and postprandial increase of gastrin levels showed a response over the upper normal range, indicating gastrin cell hyperfunction. Acid hypersecretion, both basal and after pentagastrin stimulation, was also found in the two children, confirming the biological effect of their sustained hypergastrinemia. Gastrin cell counts were within the normal range, while the number of somatostatin D cells was significantly reduced. This report stresses the importance of diagnosing antral gastrin cell hyperfunction in children because this unrecognized condition may manifest with serious complications (bleeding) or nonspecific abdominal symptoms.

Original languageEnglish
Pages (from-to)1547-1551
Number of pages5
Issue number6
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Gastroenterology


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