A description is given of acute renal failure in 6 patients with systemic lupus erythematosus. Kidney biopsy showed diffuse intracapillary proliferation, and in some glomeruli there was extracapillary proliferation. Other characteristic lesions were 'iron wire' thickening of the basement membrane and intraglomerular thrombi. In 2 patients, there was necrotising arteriolitis. Treatment included heparin as an anticoagulant, large doses of steroids and dialysis for anuria. All patients showed improvement of renal function after a period of anuria of 4 to 30 days. One patient died of gastric hemorrhage after a satisfactory improvement of creatinine clearance. All the other cases are living, with normal or subnormal renal function. One case had renal function of only medium grade.
|Translated title of the contribution||Anuria during acute lupus|
|Number of pages||6|
|Publication status||Published - 1974|
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