Anxiety, depression, and quality of life in Parkinson's disease: The implications of multidisciplinary treatment

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Anxiety and depression in Parkinson's disease (PD) reduce well-being of the patients. Emotional alterations influence motor skills and cognitive performance; moreover, they contribute significantly and independently to worsen rehabilitative treatment response. We investigated anxiety, depression, and quality of life in PD patients subjected to multidisciplinary rehabilitative training. The self-controlled study included 100 PD patients (49 males and 51 females with the mean age of 64.66 years) admitted to 60 days hospitalization rehabilitative program, between January 2017 and December 2018. Motor, cognitive, linguistic abilities, and functional independence were evaluated at admission (T0 baseline visit) and 60 days after (T1) the multidisciplinary rehabilitation including motor exercises, speech therapies, and cognitive intervention. The multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood, motor abilities, autonomy in the activities of daily life, perception of quality of life, cognitive performance and speech skills. Non-motor symptoms may worsen severe disability and reduce quality of life. They are often poorly recognized and inadequately treated. Nonetheless, multidisciplinary rehabilitative training represents an optimal strategy to improve disease management. The study was approved by Istituito di Ricovero e Cura a Carattere Scientifico (IRCCS) Centro Neurolesi 'Bonino-Pulejo' Ethical Committee (approval No. 6/2016) in June 2016.

Original languageEnglish
Pages (from-to)587-590
Number of pages4
JournalNeural Regeneration Research
Issue number3
Publication statusPublished - Mar 2021


  • anxiety
  • depression
  • multidisciplinary rehabilitation
  • Parkinson's disease

ASJC Scopus subject areas

  • Developmental Neuroscience


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