Anxiety sensitivity and 35% CO2 reactivity in patients with panic disorder

Giampaolo Perna; Pietra Romano; Daniela Caldirola; Michele Cucchi; Laura Bellodi

doi:10.1016/S0022-3999(02)00468-3

Anxiety sensitivity and 35% CO2 reactivity in patients with panic disorder

Giampaolo Perna, Pietra Romano, Daniela Caldirola, Michele Cucchi, Laura Bellodi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO ₂) challenge in panic disorder (PD). Methods: One-hundred eight patients with PD underwent the 35% CO₂ challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of AS as a predictor of CO₂-induced anxiety. Results: Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO₂ but not subjective induced anxiety. Conclusion: These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO₂ but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.

Original language	English
Pages (from-to)	573-577
Number of pages	5
Journal	Journal of Psychosomatic Research
Volume	54
Issue number	6
DOIs	https://doi.org/10.1016/S0022-3999(02)00468-3
Publication status	Published - Jun 2003

Keywords

Anxiety sensitivity
Carbon dioxide
Cognitive
Panic disorder

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Psychology(all)

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title = "Anxiety sensitivity and 35% CO2 reactivity in patients with panic disorder",

abstract = "Objective: The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO 2) challenge in panic disorder (PD). Methods: One-hundred eight patients with PD underwent the 35% CO2 challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of AS as a predictor of CO2-induced anxiety. Results: Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO2 but not subjective induced anxiety. Conclusion: These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO2 but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.",

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AU - Perna, Giampaolo

AU - Romano, Pietra

AU - Caldirola, Daniela

AU - Cucchi, Michele

AU - Bellodi, Laura

PY - 2003/6

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N2 - Objective: The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO 2) challenge in panic disorder (PD). Methods: One-hundred eight patients with PD underwent the 35% CO2 challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of AS as a predictor of CO2-induced anxiety. Results: Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO2 but not subjective induced anxiety. Conclusion: These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO2 but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.

AB - Objective: The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO 2) challenge in panic disorder (PD). Methods: One-hundred eight patients with PD underwent the 35% CO2 challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of AS as a predictor of CO2-induced anxiety. Results: Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO2 but not subjective induced anxiety. Conclusion: These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO2 but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.

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