Anxiolytic activity on locus coeruleus-mediated suppression of muricidal aggression

Włodzimier Kozak, Luigi Valzelli, Silvio Garattini

Research output: Contribution to journalArticle

Abstract

The evidence suggests that stimulation of brain noradrenergic neurons plays an inhibitory role in rat mouse-killing (muricidal) aggression. Anxiolytic benzodiazepines inhibit locus coeruleus activity and previous data showed that chlordiazepoxide was capable of antagonizing the locus coeruleus-mediated suppression of muricidal aggression. The present experiments showed that this effect is common to new anxiolytic triazolobenzodiazepines and to other non-benzodiazepine derivatives with anxiolytic activity. In this framework, 10 mg/kg of buspirone, of 1-pyrimidine-piperazine and of MJ-13805 proved to be as active as 2.5 mg/kg of alprazolam and as 5 mg/kg of chlordiazepoxide in inhibiting the locus coeruleus-mediated suppression of muricidal aggression.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalEuropean Journal of Pharmacology
Volume105
Issue number3-4
DOIs
Publication statusPublished - Oct 15 1984

Keywords

  • Benzodiazepines
  • Locus coeruleus stimulation
  • Muricidal aggression
  • Non-benzodiazepine anxiolytic

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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