Aortic expansion after acute type B aortic dissection

Frederik H W Jonker, Santi Trimarchi, Vincenzo Rampoldi, Himanshu J. Patel, Patrick O'Gara, Mark D. Peterson, Rossella Fattori, Frans L. Moll, Matthias Voehringer, Reed E. Pyeritz, Stuart Hutchison, Daniel Montgomery, Eric M. Isselbacher, Christoph A. Nienaber, Kim A. Eagle

Research output: Contribution to journalArticle

Abstract

Background: A considerable number of patients with acute type B aortic dissection (ABAD) treated with medical management alone will exhibit aortic enlargement during follow-up, which could lead to aortic aneurysm and rupture. The purpose of this study was to investigate predictors of aortic expansion among ABAD patients enrolled in the International Registry of Acute Aortic Dissection. Methods: We analyzed 191 ABAD patients treated with medical therapy alone enrolled in the registry between 1996 and 2010, with available descending aortic diameter measurements at admission and during follow-up. The annual aortic expansion rate was calculated for all patients, and multivariate regression analysis was used to investigate factors affecting the expansion rate. Results: Aortic expansion was observed in 59% of ABAD patients; mean expansion rate was 1.7 ± 7 mm/y. In multivariate analysis, white race (regression coefficient [RC], 4.6; 95% confidence interval [CI], 1.4 to 7.7) and an initial aortic diameter less than 4.0 cm (RC, 6.3; 95% CI, 4.0 to 8.6) were associated with increased aortic expansion. Female sex (RC, -3.8; 95% CI, -6.1 to -1.4), intramural hematoma (RC, -3.8; 95% CI, -6.5 to -1.1), and use of calcium-channel blockers (RC, -3.8; 95% CI, -6.2 to -1.3) were associated with decreased aortic expansion. Conclusions: White race and a small initial aortic diameter were associated with increased aortic expansion during follow-up, and decreased aortic expansion was observed among women, patients with intramural hematoma, and those on calcium-channel blockers. These data raise the possibility that the use of calcium-channel blockers after ABAD may reduce the rate of aortic expansion, and therefore further investigation is warranted.

Original languageEnglish
Pages (from-to)1223-1229
Number of pages7
JournalAnnals of Thoracic Surgery
Volume94
Issue number4
DOIs
Publication statusPublished - Oct 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

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    Jonker, F. H. W., Trimarchi, S., Rampoldi, V., Patel, H. J., O'Gara, P., Peterson, M. D., Fattori, R., Moll, F. L., Voehringer, M., Pyeritz, R. E., Hutchison, S., Montgomery, D., Isselbacher, E. M., Nienaber, C. A., & Eagle, K. A. (2012). Aortic expansion after acute type B aortic dissection. Annals of Thoracic Surgery, 94(4), 1223-1229. https://doi.org/10.1016/j.athoracsur.2012.05.040