Aortic stenosis: Insights on pathogenesis and clinical implications

Patrizia Carità, Giuseppe Coppola, Giuseppina Novo, Giuseppa Caccamo, Marco Guglielmo, Fabio Balasus, Salvatore Novo, Sebastiano Castrovinci, Marco Moscarelli, Khalil Fattouch, Egle Corrado

Research output: Contribution to journalArticle

Abstract

Aortic stenosis (AS) is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is referred to as degenerative calcific processes. Scientific evidence suggests the involvement of an active "atherosclerosis-like" pathogenesis in the initiation phase of degenerative AS. To the contrary, the progression could be driven by different forces (such as mechanical stress, genetic factors and interaction between inflammation and calcification). The improved understanding presents potentially new therapeutic targets for preventing and inhibiting the development and progression of the disease. Furthermore, in clinical practice the management of AS patients implies the evaluation of generalized atherosclerotic manifestations (i.e., in the coronary and carotid arteries) even for prognostic reasons. In counselling elderly patients, the risk stratification should address individual frailty beyond the generic risk scores. In these regard, the co-morbidities, and in particular those linked to the global atherosclerotic burden, should be carefully investigated in order to define the risk/benefit ratio for invasive treatment strategies. We present a detailed overview of insights in pathogenesis of AS with possible practical implications.

Original languageEnglish
Pages (from-to)489-498
Number of pages10
JournalJournal of Geriatric Cardiology
Volume13
Issue number6
DOIs
Publication statusPublished - 2016

Fingerprint

Aortic Valve Stenosis
Biological Phenomena
Heart Valve Diseases
Mechanical Stress
Practice Management
Carotid Arteries
Disease Progression
Counseling
Atherosclerosis
Coronary Vessels
Odds Ratio
Inflammation
Morbidity
Therapeutics
Population

Keywords

  • Atherosclerosis
  • Clinical implications
  • Degenerative aortic stenosis
  • Pathogenesis
  • The elderly

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Geriatrics and Gerontology

Cite this

Aortic stenosis : Insights on pathogenesis and clinical implications. / Carità, Patrizia; Coppola, Giuseppe; Novo, Giuseppina; Caccamo, Giuseppa; Guglielmo, Marco; Balasus, Fabio; Novo, Salvatore; Castrovinci, Sebastiano; Moscarelli, Marco; Fattouch, Khalil; Corrado, Egle.

In: Journal of Geriatric Cardiology, Vol. 13, No. 6, 2016, p. 489-498.

Research output: Contribution to journalArticle

Carità, P, Coppola, G, Novo, G, Caccamo, G, Guglielmo, M, Balasus, F, Novo, S, Castrovinci, S, Moscarelli, M, Fattouch, K & Corrado, E 2016, 'Aortic stenosis: Insights on pathogenesis and clinical implications', Journal of Geriatric Cardiology, vol. 13, no. 6, pp. 489-498. https://doi.org/10.11909/j.issn.1671-5411.2016.06.001
Carità, Patrizia ; Coppola, Giuseppe ; Novo, Giuseppina ; Caccamo, Giuseppa ; Guglielmo, Marco ; Balasus, Fabio ; Novo, Salvatore ; Castrovinci, Sebastiano ; Moscarelli, Marco ; Fattouch, Khalil ; Corrado, Egle. / Aortic stenosis : Insights on pathogenesis and clinical implications. In: Journal of Geriatric Cardiology. 2016 ; Vol. 13, No. 6. pp. 489-498.
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