APC/β-catenin deregulation in desmoid tumors: Important implications for diagnosis, prognosis, and therapy

Chiara Colombo, Dina Lev

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Understanding the molecular aberrations driving the inception and progression of desmoid tumors (DTs) is crucial to devising an effective management for these neoplasms. The APC/β-catenin pathway is known to be deregulated in DT. This chapter illuminates the molecular mechanisms of APC/β-catenin pathway signaling, elucidates the potential deregulations and mutations at play in DTs, and most importantly evaluates the possible implications of this pathway on DT diagnosis, prognosis, and therapy.

Original languageEnglish
Title of host publicationDesmoid Tumors
PublisherSpringer Netherlands
Pages29-46
Number of pages18
ISBN (Print)9789400716858, 9789400716841
DOIs
Publication statusPublished - Jan 1 2012

Keywords

  • APC
  • Mutations
  • Prognostic biomarkers
  • Sequencing
  • Targeted therapy
  • β-Catenin

ASJC Scopus subject areas

  • Medicine(all)

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