APE1/Ref-1 in Alzheimer's disease: An immunohistochemical study

Gabriella Marcon, Gianluca Tell, Lorena Perrone, Rita Garbelli, Franco Quadrifoglio, Fabrizio Tagliavini, Giorgio Giaccone

Research output: Contribution to journalArticle

Abstract

The oxidative injury in Alzheimer's disease (AD), in which amyloid β protein induces production of reactive oxygen species, may be cause of neurodegeneration. APE1/Ref-1 is a protein involved in DNA repair and in redox co-activating function over different transcription factors. We investigated by immunohistochemistry using a highly specific monoclonal antibody, the localization of APE1/Ref-1 in autoptic and bioptic AD brain tissues in comparison with brains with unrelated pathological or normal conditions. Reliable APE1/Ref-1 immunostaining was obtained in biopsies, but not in autoptic tissues. An increased nuclear expression of APE1/Ref-1 in AD cerebral cortex supports the view that the cellular adaptive response to the oxidative stress condition is involved in the pathogenesis of this disease.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalNeuroscience Letters
Volume466
Issue number3
DOIs
Publication statusPublished - Dec 11 2009

    Fingerprint

Keywords

  • Alzheimer's disease
  • APE1/Ref-1
  • Neurodegenerative diseases
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this