Abstract
Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).
| Original language | English |
|---|---|
| Pages (from-to) | 1211-1229 |
| Number of pages | 19 |
| Journal | Brain |
| Volume | 110 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1987 |
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ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Mathematics(all)
- Statistics and Probability
- Agricultural and Biological Sciences (miscellaneous)
- Clinical Neurology
- Neuroscience(all)
Cite this
Aphasia and neglect after subcortical stroke : A clinical/cerebral PERFUSION correlation study. / Perani, Daniela; Vallar, Giuseppe; Cappa, Stefano; Messa, Cristina; Fazio, Ferruccio.
In: Brain, Vol. 110, No. 5, 10.1987, p. 1211-1229.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aphasia and neglect after subcortical stroke
T2 - A clinical/cerebral PERFUSION correlation study
AU - Perani, Daniela
AU - Vallar, Giuseppe
AU - Cappa, Stefano
AU - Messa, Cristina
AU - Fazio, Ferruccio
PY - 1987/10
Y1 - 1987/10
N2 - Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).
AB - Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).
UR - http://www.scopus.com/inward/record.url?scp=0023635801&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023635801&partnerID=8YFLogxK
U2 - 10.1093/brain/110.5.1211
DO - 10.1093/brain/110.5.1211
M3 - Article
VL - 110
SP - 1211
EP - 1229
JO - Brain
JF - Brain
SN - 0006-8950
IS - 5
ER -