Aphasia and neglect after subcortical stroke: A clinical/cerebral PERFUSION correlation study

Daniela Perani, Giuseppe Vallar, Stefano Cappa, Cristina Messa, Ferruccio Fazio

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Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).

Original languageEnglish
Pages (from-to)1211-1229
Number of pages19
Issue number5
Publication statusPublished - Oct 1987

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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