Aphasia and neglect after subcortical stroke

A clinical/cerebral PERFUSION correlation study

Daniela Perani, Giuseppe Vallar, Stefano Cappa, Cristina Messa, Ferruccio Fazio

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).

Original languageEnglish
Pages (from-to)1211-1229
Number of pages19
JournalBrain
Volume110
Issue number5
DOIs
Publication statusPublished - Oct 1987

Fingerprint

Aphasia
Stroke
stroke
Brain
Computerized Tomography
Computerized tomography
Rearrangement
brain
Photon
Photons
tomography
Single-Photon Emission-Computed Tomography
lesions (animal)
Perfusion
Psychology
Neglect

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Aphasia and neglect after subcortical stroke : A clinical/cerebral PERFUSION correlation study. / Perani, Daniela; Vallar, Giuseppe; Cappa, Stefano; Messa, Cristina; Fazio, Ferruccio.

In: Brain, Vol. 110, No. 5, 10.1987, p. 1211-1229.

Research output: Contribution to journalArticle

Perani, Daniela ; Vallar, Giuseppe ; Cappa, Stefano ; Messa, Cristina ; Fazio, Ferruccio. / Aphasia and neglect after subcortical stroke : A clinical/cerebral PERFUSION correlation study. In: Brain. 1987 ; Vol. 110, No. 5. pp. 1211-1229.
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