Aphasia and neglect after subcortical stroke: A clinical/cerebral PERFUSION correlation study

Daniela Perani; Giuseppe Vallar; Stefano Cappa; Cristina Messa; Ferruccio Fazio

doi:10.1093/brain/110.5.1211

Aphasia and neglect after subcortical stroke: A clinical/cerebral PERFUSION correlation study

Daniela Perani, Giuseppe Vallar, Stefano Cappa, Cristina Messa, Ferruccio Fazio

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Abstract

Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N¹-trimethyl-N¹-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).

Original language	English
Pages (from-to)	1211-1229
Number of pages	19
Journal	Brain
Volume	110
Issue number	5
DOIs	https://doi.org/10.1093/brain/110.5.1211
Publication status	Published - Oct 1987

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Mathematics(all)
Statistics and Probability
Agricultural and Biological Sciences (miscellaneous)
Clinical Neurology
Neuroscience(all)

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10.1093/brain/110.5.1211

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title = "Aphasia and neglect after subcortical stroke: A clinical/cerebral PERFUSION correlation study",

abstract = "Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).",

author = "Daniela Perani and Giuseppe Vallar and Stefano Cappa and Cristina Messa and Ferruccio Fazio",

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AU - Perani, Daniela

AU - Vallar, Giuseppe

AU - Cappa, Stefano

AU - Messa, Cristina

AU - Fazio, Ferruccio

PY - 1987/10

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N2 - Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).

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Aphasia and neglect after subcortical stroke: A clinical/cerebral PERFUSION correlation study

Abstract

ASJC Scopus subject areas

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