Aphasia and neglect after subcortical stroke: A clinical/cerebral PERFUSION correlation study

Daniela Perani, Giuseppe Vallar, Stefano Cappa, Cristina Messa, Ferruccio Fazio

Research output: Contribution to journalArticle

Abstract

Sixteen patients with unilateral subcortical haemorrhagic or ischaemic stroke, confirmed by CT, were evaluated for the presence of aphasia and neglect. Compared with patients without neuro-psychological deficits, left brain-damaged aphasic and right brain-damaged neglect patients showed a significantly greater reduction of cortical perfusion on N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-l, 3-propanediamine 2 HC1 1-123 (HIPDM) and single photon emission computerized tomography (SPECT). These results suggest that major cortical derangement is the crucial factor for the appearance of aphasia or neglect after a subcortical stroke. These remote effects, which are related to the size of the subcortical lesion, are interpreted in terms of interruption of neural connections (diaschisis).

Original languageEnglish
Pages (from-to)1211-1229
Number of pages19
JournalBrain
Volume110
Issue number5
DOIs
Publication statusPublished - Oct 1987

Fingerprint

Aphasia
Stroke
stroke
Brain
Computerized Tomography
Computerized tomography
Rearrangement
brain
Photon
Photons
tomography
Single-Photon Emission-Computed Tomography
lesions (animal)
Perfusion
Psychology
Neglect

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Aphasia and neglect after subcortical stroke : A clinical/cerebral PERFUSION correlation study. / Perani, Daniela; Vallar, Giuseppe; Cappa, Stefano; Messa, Cristina; Fazio, Ferruccio.

In: Brain, Vol. 110, No. 5, 10.1987, p. 1211-1229.

Research output: Contribution to journalArticle

Perani, Daniela ; Vallar, Giuseppe ; Cappa, Stefano ; Messa, Cristina ; Fazio, Ferruccio. / Aphasia and neglect after subcortical stroke : A clinical/cerebral PERFUSION correlation study. In: Brain. 1987 ; Vol. 110, No. 5. pp. 1211-1229.
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