APLASTIC CRISIS DUE TO PARVOVIRUS INFECTION IN PYRUVATE KINASE DEFICIENCY

J. R. Duncan, M. D. Cappellini, M. J. Anderson, C. G. Potter, J. B. Kurtz, D. J. Weatherall

Research output: Contribution to journalArticle

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Abstract

A thirteen-year-old boy with congenital haemolytic anaemia due to pyruvate kinase (PK) deficiency had an aplastic crisis. A serum parvovirus-like virus (SPLV) was demonstrated in the blood by electron microscopy and, subsequently, IgM and IgG antibodies to the prototype SPLV B19 were detected. In an attempt to define the level of erythropoiesis that is involved in parvovirus-induced bone marrow suppression, the levels of circulating early erythroid progenitors (burst forming units erythroid, BFU-E) were monitored during the crisis and recovery period. The virus-containing plasma inhibited the formation of BFU-Es from non-immune subjects and this effect was neutralised by convalescent serum. Colony forming units granulocyte-macrophage (CFU-GM) were also inhibited but this was probably non-specific since neutralisation did not reverse the effect. These experiments, together with the clinical data, suggest a selective effect of SPLV at the stage of erythroid progenitors.

Original languageEnglish
Pages (from-to)14-16
Number of pages3
JournalLancet
Volume322
Issue number8340
DOIs
Publication statusPublished - Jul 2 1983

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Parvoviridae Infections
Parvovirus
Viruses
Serum
Congenital Hemolytic Anemia
Human Parvovirus B19
Granulocyte-Macrophage Progenitor Cells
Erythroid Precursor Cells
Erythropoiesis
Immunoglobulin M
Electron Microscopy
Immunoglobulin G
Bone Marrow
Pyruvate Kinase Deficiency of Red Cells
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Duncan, J. R., Cappellini, M. D., Anderson, M. J., Potter, C. G., Kurtz, J. B., & Weatherall, D. J. (1983). APLASTIC CRISIS DUE TO PARVOVIRUS INFECTION IN PYRUVATE KINASE DEFICIENCY. Lancet, 322(8340), 14-16. https://doi.org/10.1016/S0140-6736(83)90005-3

APLASTIC CRISIS DUE TO PARVOVIRUS INFECTION IN PYRUVATE KINASE DEFICIENCY. / Duncan, J. R.; Cappellini, M. D.; Anderson, M. J.; Potter, C. G.; Kurtz, J. B.; Weatherall, D. J.

In: Lancet, Vol. 322, No. 8340, 02.07.1983, p. 14-16.

Research output: Contribution to journalArticle

Duncan, JR, Cappellini, MD, Anderson, MJ, Potter, CG, Kurtz, JB & Weatherall, DJ 1983, 'APLASTIC CRISIS DUE TO PARVOVIRUS INFECTION IN PYRUVATE KINASE DEFICIENCY', Lancet, vol. 322, no. 8340, pp. 14-16. https://doi.org/10.1016/S0140-6736(83)90005-3
Duncan, J. R. ; Cappellini, M. D. ; Anderson, M. J. ; Potter, C. G. ; Kurtz, J. B. ; Weatherall, D. J. / APLASTIC CRISIS DUE TO PARVOVIRUS INFECTION IN PYRUVATE KINASE DEFICIENCY. In: Lancet. 1983 ; Vol. 322, No. 8340. pp. 14-16.
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