Apocalypsal versus apocryphal

The role of retroviruses in primary biliary cirrhosis

M. Eric Gershwin, Carlo Selmi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The etiology of primary biliary cirrhosis (PBC), much like that of other autoimmune diseases, remains enigmatic. In the case of PBC, several candidates have been proposed, including bacteria, chemicals, and retroviruses. The support for a retroviral etiology has led to a pilot therapeutical interventional program. However, there is limited objective data which can be used to support such a thesis. Until reproducible and mechanistically sound data can be offered, we suggest that pharmaceutical trials are unrealistic and should be discouraged.

Original languageEnglish
Pages (from-to)2356-2358
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume99
Issue number12
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Biliary Liver Cirrhosis
Retroviridae
Autoimmune Diseases
Bacteria
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Apocalypsal versus apocryphal : The role of retroviruses in primary biliary cirrhosis. / Gershwin, M. Eric; Selmi, Carlo.

In: American Journal of Gastroenterology, Vol. 99, No. 12, 12.2004, p. 2356-2358.

Research output: Contribution to journalArticle

@article{0be294606c47435cb1fa219de32807e8,
title = "Apocalypsal versus apocryphal: The role of retroviruses in primary biliary cirrhosis",
abstract = "The etiology of primary biliary cirrhosis (PBC), much like that of other autoimmune diseases, remains enigmatic. In the case of PBC, several candidates have been proposed, including bacteria, chemicals, and retroviruses. The support for a retroviral etiology has led to a pilot therapeutical interventional program. However, there is limited objective data which can be used to support such a thesis. Until reproducible and mechanistically sound data can be offered, we suggest that pharmaceutical trials are unrealistic and should be discouraged.",
author = "Gershwin, {M. Eric} and Carlo Selmi",
year = "2004",
month = "12",
doi = "10.1111/j.1572-0241.2004.41157.x",
language = "English",
volume = "99",
pages = "2356--2358",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Apocalypsal versus apocryphal

T2 - The role of retroviruses in primary biliary cirrhosis

AU - Gershwin, M. Eric

AU - Selmi, Carlo

PY - 2004/12

Y1 - 2004/12

N2 - The etiology of primary biliary cirrhosis (PBC), much like that of other autoimmune diseases, remains enigmatic. In the case of PBC, several candidates have been proposed, including bacteria, chemicals, and retroviruses. The support for a retroviral etiology has led to a pilot therapeutical interventional program. However, there is limited objective data which can be used to support such a thesis. Until reproducible and mechanistically sound data can be offered, we suggest that pharmaceutical trials are unrealistic and should be discouraged.

AB - The etiology of primary biliary cirrhosis (PBC), much like that of other autoimmune diseases, remains enigmatic. In the case of PBC, several candidates have been proposed, including bacteria, chemicals, and retroviruses. The support for a retroviral etiology has led to a pilot therapeutical interventional program. However, there is limited objective data which can be used to support such a thesis. Until reproducible and mechanistically sound data can be offered, we suggest that pharmaceutical trials are unrealistic and should be discouraged.

UR - http://www.scopus.com/inward/record.url?scp=11144330924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144330924&partnerID=8YFLogxK

U2 - 10.1111/j.1572-0241.2004.41157.x

DO - 10.1111/j.1572-0241.2004.41157.x

M3 - Article

VL - 99

SP - 2356

EP - 2358

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 12

ER -