Apolipoprotein A-II modulates HDL remodeling in plasma

Laura Calabresi, Cristina Banfi, Cesare R. Sirtori, Guido Franceschini

Research output: Contribution to journalArticlepeer-review

Abstract

Native and reduced-carboxamidomethylated (RCM) HDL3 are incubated with a lipoprotein-depleted plasma fraction in the presence of triacylglycerol-rich particles isolated from Intralipid. Unmodified HDL3 are mainly converted into large HDL2b particles (diameter: 9.84 ± 0.15 nm); RCM-HDL3 are transformed into both large HDL2b (9.76 ± 0.10 nm) and small HDL3c (7.68 ± 0.07 nm). These findings indicate that the apo A-II dimers participate in the remodeling of HDL, by inhibiting the formation of small HDL particles.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1124
Issue number2
DOIs
Publication statusPublished - Mar 4 1992

Keywords

  • Apolipoprotein A-II
  • HDL

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Endocrinology

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