TY - JOUR
T1 - Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G
T2 - A possible role in the resistance to HIV of HIV-exposed seronegative individuals
AU - Biasin, Mara
AU - Piacentini, Luca
AU - Lo Caputo, Sergio
AU - Kanari, Yasuyoshi
AU - Magri, Giuliana
AU - Trabattoni, Daria
AU - Naddeo, Valentina
AU - Lopalco, Lucia
AU - Clivio, Alberto
AU - Cesana, Eugenio
AU - Fasano, Francesca
AU - Bergamaschi, Cristina
AU - Mazzotta, Francesco
AU - Miyazawa, Masaaki
AU - Clerici, Mario
PY - 2007/4/1
Y1 - 2007/4/1
N2 - Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs) - mainly CD14 + cells - and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1Ba-L R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.
AB - Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs) - mainly CD14 + cells - and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1Ba-L R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.
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U2 - 10.1086/511988
DO - 10.1086/511988
M3 - Article
C2 - 17330785
AN - SCOPUS:33947416193
VL - 195
SP - 960
EP - 964
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 7
ER -