Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: A possible role in the resistance to HIV of HIV-exposed seronegative individuals

Mara Biasin; Luca Piacentini; Sergio Lo Caputo; Yasuyoshi Kanari; Giuliana Magri; Daria Trabattoni; Valentina Naddeo; Lucia Lopalco; Alberto Clivio; Eugenio Cesana; Francesca Fasano; Cristina Bergamaschi; Francesco Mazzotta; Masaaki Miyazawa; Mario Clerici

doi:10.1086/511988

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: A possible role in the resistance to HIV of HIV-exposed seronegative individuals

Mara Biasin, Luca Piacentini, Sergio Lo Caputo, Yasuyoshi Kanari, Giuliana Magri, Daria Trabattoni, Valentina Naddeo, Lucia Lopalco, Alberto Clivio, Eugenio Cesana, Francesca Fasano, Cristina Bergamaschi, Francesco Mazzotta, Masaaki Miyazawa, Mario Clerici

Research output: Contribution to journal › Article › peer-review

Abstract

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs) - mainly CD14 ⁺ cells - and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1_Ba-L R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.

Original language	English
Pages (from-to)	960-964
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	195
Issue number	7
DOIs	https://doi.org/10.1086/511988
Publication status	Published - Apr 1 2007

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Immunology

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Biasin, M., Piacentini, L., Lo Caputo, S., Kanari, Y., Magri, G., Trabattoni, D., Naddeo, V., Lopalco, L., Clivio, A., Cesana, E., Fasano, F., Bergamaschi, C., Mazzotta, F., Miyazawa, M., & Clerici, M. (2007). Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: A possible role in the resistance to HIV of HIV-exposed seronegative individuals. Journal of Infectious Diseases, 195(7), 960-964. https://doi.org/10.1086/511988

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G : A possible role in the resistance to HIV of HIV-exposed seronegative individuals. / Biasin, Mara; Piacentini, Luca; Lo Caputo, Sergio; Kanari, Yasuyoshi; Magri, Giuliana; Trabattoni, Daria; Naddeo, Valentina; Lopalco, Lucia; Clivio, Alberto; Cesana, Eugenio; Fasano, Francesca; Bergamaschi, Cristina; Mazzotta, Francesco; Miyazawa, Masaaki; Clerici, Mario.

In: Journal of Infectious Diseases, Vol. 195, No. 7, 01.04.2007, p. 960-964.

Research output: Contribution to journal › Article › peer-review

Biasin, M, Piacentini, L, Lo Caputo, S, Kanari, Y, Magri, G, Trabattoni, D, Naddeo, V, Lopalco, L, Clivio, A, Cesana, E, Fasano, F, Bergamaschi, C, Mazzotta, F, Miyazawa, M & Clerici, M 2007, 'Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: A possible role in the resistance to HIV of HIV-exposed seronegative individuals', Journal of Infectious Diseases, vol. 195, no. 7, pp. 960-964. https://doi.org/10.1086/511988

Biasin, Mara ; Piacentini, Luca ; Lo Caputo, Sergio ; Kanari, Yasuyoshi ; Magri, Giuliana ; Trabattoni, Daria ; Naddeo, Valentina ; Lopalco, Lucia ; Clivio, Alberto ; Cesana, Eugenio ; Fasano, Francesca ; Bergamaschi, Cristina ; Mazzotta, Francesco ; Miyazawa, Masaaki ; Clerici, Mario. / Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G : A possible role in the resistance to HIV of HIV-exposed seronegative individuals. In: Journal of Infectious Diseases. 2007 ; Vol. 195, No. 7. pp. 960-964.

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abstract = "Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs) - mainly CD14 + cells - and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1Ba-L R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.",

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AU - Cesana, Eugenio

AU - Fasano, Francesca

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