Apolipoprotein C-II deficiency: Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients

A. Capurso, A. M. Mogavero, F. Resta, M. Di Tommaso, P. Taverniti, F. Turturro, M. La Rosa, S. Marcovina, A. L. Catapano

Research output: Contribution to journalArticle

Abstract

Recent data suggest that mutant immunoreactive forms of apolipoprotein C-II (apoC-II) can be detected in the plasma of patients with the apoC-II deficiency syndrome. We studied the possible presence of apoC-II mutants in the plasma of two patients with apoC-II deficiency by immunological means. The patients were hypertriglyceridemic, and apoC-II was undetectable in plasma as determined by radial immunodiffision, electroimmunoassay, and immunonephelometry. Furthermore, apoC-II was undetectable either by electrophoresis or by immunoblotting in the plasma of the probands, while apoC-II was present in the plasma of their parents, although at less than half-normal concentration. Immunochemical localization of apoC-II, however, showed that the apoprotein could be detected within the enterocytes obtained from the intestinal mucosa of the patients. From these data we conclude that the Patients synthesize apoC-II, at least in the intestine.

Original languageEnglish
Pages (from-to)703-711
Number of pages9
JournalJournal of Lipid Research
Volume29
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Apolipoprotein C-II deficiency: Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients'. Together they form a unique fingerprint.

Cite this