Apolipoprotein C-II deficiency

Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients

A. Capurso, A. M. Mogavero, F. Resta, M. Di Tommaso, P. Taverniti, F. Turturro, M. La Rosa, S. Marcovina, A. L. Catapano

Research output: Contribution to journalArticle

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Abstract

Recent data suggest that mutant immunoreactive forms of apolipoprotein C-II (apoC-II) can be detected in the plasma of patients with the apoC-II deficiency syndrome. We studied the possible presence of apoC-II mutants in the plasma of two patients with apoC-II deficiency by immunological means. The patients were hypertriglyceridemic, and apoC-II was undetectable in plasma as determined by radial immunodiffision, electroimmunoassay, and immunonephelometry. Furthermore, apoC-II was undetectable either by electrophoresis or by immunoblotting in the plasma of the probands, while apoC-II was present in the plasma of their parents, although at less than half-normal concentration. Immunochemical localization of apoC-II, however, showed that the apoprotein could be detected within the enterocytes obtained from the intestinal mucosa of the patients. From these data we conclude that the Patients synthesize apoC-II, at least in the intestine.

Original languageEnglish
Pages (from-to)703-711
Number of pages9
JournalJournal of Lipid Research
Volume29
Issue number6
Publication statusPublished - 1988

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Hyperlipoproteinemia Type I
Apolipoprotein C-II
Intestinal Mucosa
Plasmas
Apoproteins
Enterocytes
Mucous Membrane
Immunoblotting
Intestines
Electrophoresis
Parents

ASJC Scopus subject areas

  • Endocrinology

Cite this

Capurso, A., Mogavero, A. M., Resta, F., Di Tommaso, M., Taverniti, P., Turturro, F., ... Catapano, A. L. (1988). Apolipoprotein C-II deficiency: Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients. Journal of Lipid Research, 29(6), 703-711.

Apolipoprotein C-II deficiency : Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients. / Capurso, A.; Mogavero, A. M.; Resta, F.; Di Tommaso, M.; Taverniti, P.; Turturro, F.; La Rosa, M.; Marcovina, S.; Catapano, A. L.

In: Journal of Lipid Research, Vol. 29, No. 6, 1988, p. 703-711.

Research output: Contribution to journalArticle

Capurso, A, Mogavero, AM, Resta, F, Di Tommaso, M, Taverniti, P, Turturro, F, La Rosa, M, Marcovina, S & Catapano, AL 1988, 'Apolipoprotein C-II deficiency: Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients', Journal of Lipid Research, vol. 29, no. 6, pp. 703-711.
Capurso A, Mogavero AM, Resta F, Di Tommaso M, Taverniti P, Turturro F et al. Apolipoprotein C-II deficiency: Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients. Journal of Lipid Research. 1988;29(6):703-711.
Capurso, A. ; Mogavero, A. M. ; Resta, F. ; Di Tommaso, M. ; Taverniti, P. ; Turturro, F. ; La Rosa, M. ; Marcovina, S. ; Catapano, A. L. / Apolipoprotein C-II deficiency : Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients. In: Journal of Lipid Research. 1988 ; Vol. 29, No. 6. pp. 703-711.
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AU - Mogavero, A. M.

AU - Resta, F.

AU - Di Tommaso, M.

AU - Taverniti, P.

AU - Turturro, F.

AU - La Rosa, M.

AU - Marcovina, S.

AU - Catapano, A. L.

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AB - Recent data suggest that mutant immunoreactive forms of apolipoprotein C-II (apoC-II) can be detected in the plasma of patients with the apoC-II deficiency syndrome. We studied the possible presence of apoC-II mutants in the plasma of two patients with apoC-II deficiency by immunological means. The patients were hypertriglyceridemic, and apoC-II was undetectable in plasma as determined by radial immunodiffision, electroimmunoassay, and immunonephelometry. Furthermore, apoC-II was undetectable either by electrophoresis or by immunoblotting in the plasma of the probands, while apoC-II was present in the plasma of their parents, although at less than half-normal concentration. Immunochemical localization of apoC-II, however, showed that the apoprotein could be detected within the enterocytes obtained from the intestinal mucosa of the patients. From these data we conclude that the Patients synthesize apoC-II, at least in the intestine.

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