Apolipoprotein e ε4 allele in alzheimer's disease and vascular dementia

Giovanni B. Frisoni, Laura Calabresi, Cristina Geroldi, Angelo Bianchetti, Antonio L. D'Acquarica, Stefano Govoni, Cesare R. Sirtori, Marco Trabitcchi, Guido Franceschini

Research output: Contribution to journalArticlepeer-review

Abstract

The frequency of the e4 allele of the apolipoprotein E (apoE) is increased in familial and sporadic late-onset Alzheimer’s disease, but its prevalence in non- Alzheimer dementias in Caucasian populations is unknown. We found that the frequency of the apoE ε4 allele was 0.45 in 93 Alzheimer’s disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the frontal type patients, and 0.18 in 51 elderly controls. The association of apoE ε4 allele is not unique to Alzheimer’s disease, and its importance as a risk factor for the disease should be reconsidered.

Original languageEnglish
Pages (from-to)240-242
Number of pages3
JournalDementia and Geriatric Cognitive Disorders
Volume5
Issue number5
DOIs
Publication statusPublished - 1994

Keywords

  • Alzheimer’s disease
  • Apolipoprotein E
  • Dementia of frontal type
  • Vascular dementia

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

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