Apolipoprotein E allele frequencies in an Italian population: Relation to age and lipid profile

G. Ruiu, M. Cassader, R. Gambino, N. Alcmanno, F. Demichieli, A. Pagano, F. Veglia, G. Pagano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Apo E phenotype and plasma Tg, Chol, LDL- Chol, HDL- Chol and Apo B levels were determined in a sample of 228 healthy Italian subjects (124 men and 104 women) aged 18–93. The allele frequencies were: ε2=0.070; ε3=0.829; φ=0.101 (among the lowest values in the literature). Division of the sample into four age groups indicated that ε4 frequency decreased with age to 0 in persons aged over 75. Covariance analysis of the influence of each allele on plasma lipids showed that ε4 was significantly associated with the highest hol, LDL- Chol and Apo B levels. These data are evidence of the influence of ε4 on Chol metabolism in an Italian population. They also show that its frequency decreases with age.(Aging Clin. Exp. Res. 7: 185–189, 1995)

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalAging clinical and experimental research
Volume7
Issue number4
DOIs
Publication statusPublished - 1995

Fingerprint

Apolipoproteins B
Apolipoproteins E
Gene Frequency
Lipids
Population
Healthy Volunteers
Age Groups
Alleles
Phenotype
oxidized low density lipoprotein

Keywords

  • Aging
  • Apo B
  • Apolipoprotein E phenotype
  • cholesterol
  • LDL-cholesterol

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Ruiu, G., Cassader, M., Gambino, R., Alcmanno, N., Demichieli, F., Pagano, A., ... Pagano, G. (1995). Apolipoprotein E allele frequencies in an Italian population: Relation to age and lipid profile. Aging clinical and experimental research, 7(4), 185-189. https://doi.org/10.1007/BF03324333

Apolipoprotein E allele frequencies in an Italian population : Relation to age and lipid profile. / Ruiu, G.; Cassader, M.; Gambino, R.; Alcmanno, N.; Demichieli, F.; Pagano, A.; Veglia, F.; Pagano, G.

In: Aging clinical and experimental research, Vol. 7, No. 4, 1995, p. 185-189.

Research output: Contribution to journalArticle

Ruiu, G, Cassader, M, Gambino, R, Alcmanno, N, Demichieli, F, Pagano, A, Veglia, F & Pagano, G 1995, 'Apolipoprotein E allele frequencies in an Italian population: Relation to age and lipid profile', Aging clinical and experimental research, vol. 7, no. 4, pp. 185-189. https://doi.org/10.1007/BF03324333
Ruiu, G. ; Cassader, M. ; Gambino, R. ; Alcmanno, N. ; Demichieli, F. ; Pagano, A. ; Veglia, F. ; Pagano, G. / Apolipoprotein E allele frequencies in an Italian population : Relation to age and lipid profile. In: Aging clinical and experimental research. 1995 ; Vol. 7, No. 4. pp. 185-189.
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