Apolipoprotein E and alpha brain rhythms in mild cognitive impairment

A multicentric electroencephalogram study

Claudio Babiloni, Luisa Benussi, Giuliano Binetti, Emanuele Cassetta, Gloria Dal Forno, Claudio Del Percio, Florinda Ferreri, Raffaele Ferri, Giovanni Frisoni, Roberta Ghidoni, Carlo Miniussi, Guido Rodriguez, Gian Luca Romani, Rosanna Squitti, Maria Carla Ventriglia, Paolo M. Rossini

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objective: Relationships between the apolipoprotein E ε4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer's disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of ε4 affects sources of resting EEG rhythms in both MCI and AD subjects. Methods: We enrolled 89 MCI subjects (34.8% with ε4) and 103 AD patients (50.4% with ε4). Resting eyes-closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), and beta 2 (20-30Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results: Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the ε4 allele than in those not carrying the ε4 allele (p <0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD. Interpretation: Such a demonstration motivates future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects.

Original languageEnglish
Pages (from-to)323-334
Number of pages12
JournalAnnals of Neurology
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 2006

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Alpha Rhythm
Apolipoproteins E
Electroencephalography
Alzheimer Disease
Brain
Alleles
Periodicity
Genotype
Apolipoprotein E4
Phenotype
Electromagnetic Phenomena
Cognitive Dysfunction
Tomography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Apolipoprotein E and alpha brain rhythms in mild cognitive impairment : A multicentric electroencephalogram study. / Babiloni, Claudio; Benussi, Luisa; Binetti, Giuliano; Cassetta, Emanuele; Dal Forno, Gloria; Del Percio, Claudio; Ferreri, Florinda; Ferri, Raffaele; Frisoni, Giovanni; Ghidoni, Roberta; Miniussi, Carlo; Rodriguez, Guido; Romani, Gian Luca; Squitti, Rosanna; Ventriglia, Maria Carla; Rossini, Paolo M.

In: Annals of Neurology, Vol. 59, No. 2, 02.2006, p. 323-334.

Research output: Contribution to journalArticle

Babiloni, Claudio ; Benussi, Luisa ; Binetti, Giuliano ; Cassetta, Emanuele ; Dal Forno, Gloria ; Del Percio, Claudio ; Ferreri, Florinda ; Ferri, Raffaele ; Frisoni, Giovanni ; Ghidoni, Roberta ; Miniussi, Carlo ; Rodriguez, Guido ; Romani, Gian Luca ; Squitti, Rosanna ; Ventriglia, Maria Carla ; Rossini, Paolo M. / Apolipoprotein E and alpha brain rhythms in mild cognitive impairment : A multicentric electroencephalogram study. In: Annals of Neurology. 2006 ; Vol. 59, No. 2. pp. 323-334.
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T1 - Apolipoprotein E and alpha brain rhythms in mild cognitive impairment

T2 - A multicentric electroencephalogram study

AU - Babiloni, Claudio

AU - Benussi, Luisa

AU - Binetti, Giuliano

AU - Cassetta, Emanuele

AU - Dal Forno, Gloria

AU - Del Percio, Claudio

AU - Ferreri, Florinda

AU - Ferri, Raffaele

AU - Frisoni, Giovanni

AU - Ghidoni, Roberta

AU - Miniussi, Carlo

AU - Rodriguez, Guido

AU - Romani, Gian Luca

AU - Squitti, Rosanna

AU - Ventriglia, Maria Carla

AU - Rossini, Paolo M.

PY - 2006/2

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N2 - Objective: Relationships between the apolipoprotein E ε4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer's disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of ε4 affects sources of resting EEG rhythms in both MCI and AD subjects. Methods: We enrolled 89 MCI subjects (34.8% with ε4) and 103 AD patients (50.4% with ε4). Resting eyes-closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), and beta 2 (20-30Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results: Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the ε4 allele than in those not carrying the ε4 allele (p <0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD. Interpretation: Such a demonstration motivates future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects.

AB - Objective: Relationships between the apolipoprotein E ε4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer's disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of ε4 affects sources of resting EEG rhythms in both MCI and AD subjects. Methods: We enrolled 89 MCI subjects (34.8% with ε4) and 103 AD patients (50.4% with ε4). Resting eyes-closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), and beta 2 (20-30Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results: Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the ε4 allele than in those not carrying the ε4 allele (p <0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD. Interpretation: Such a demonstration motivates future genotype-EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects.

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