Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1- antichymotrypsin in Alzheimer's disease and vascular dementia

T. Rodriguez Martin, A. M. Calella, S. Silva, E. Munna, P. Modena, R. Chiesa, S. Terrevazzi, R. M. Ruggieri, R. Palermo, F. Piccoli, R. Confalonieri, P. Tiraboschi, C. Fragiacomo, P. Quadri, U. Lucca, Gianluigi Forloni

Research output: Contribution to journalArticle

Abstract

Apolipoprotein E (ApoE) genotypes, presenilin 1 (PS-1) and α1- antichymotrypsin (ACT) polymorphism and the association of the genotypes were examined in patients with Alzheimer's disease (AD, n = 121) or vascular dementia (VD, n = 68) in comparison with elderly controls (n = 125). The frequency of the ApoE ε4 allele was significantly increased both in late- onset AD (0.35) and in VD (0.17); the frequency of ApoE ε2 was significantly reduced in AD, but it was similar in VD and controls. The presence of the allele 1 of PS-1 intronic polymorphism was not associated with AD or VD and was not influenced by the ApoE genotypes. Also, the frequency of allele A of the intronic polymorphism of ACT was similar in AD, VD and controls and it was not altered by ApoE or PS-1 genotypes. The results confirm the association between ApoE ε4 and AD and indicate an increase in ApoE ε4 in Vd, too. A potential protective role of ApoE ε2 is also suggested for late- onset AD but not for VD. No association was shown between ACT allele A and PS-1 allele 1 in AD or VD. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume11
Issue number5
Publication statusPublished - 2000

Keywords

  • α-Antichymotrypsin
  • β- Amyloid
  • Alzheimer's disease
  • Apolipoprotein E
  • Intronic polymorphism
  • Presenilin 1
  • Vascular dementia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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    Martin, T. R., Calella, A. M., Silva, S., Munna, E., Modena, P., Chiesa, R., Terrevazzi, S., Ruggieri, R. M., Palermo, R., Piccoli, F., Confalonieri, R., Tiraboschi, P., Fragiacomo, C., Quadri, P., Lucca, U., & Forloni, G. (2000). Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1- antichymotrypsin in Alzheimer's disease and vascular dementia. Dementia and Geriatric Cognitive Disorders, 11(5), 239-244.