Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy

M. Tabaton, M. Rolleri, P. Masturzo, S. Cammarata, G. Angelini, L. A. Hansen, T. Saitoh, R. B. Petersen, G. Perry, P. Richey, P. Gambetti, S. Bertolini

Research output: Contribution to journalArticle

Abstract

We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This suggests that in Alzheimer's disease the increased frequency of ApoE element 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition.

Original languageEnglish
Pages (from-to)1764-1765
Number of pages2
JournalNeurology
Volume45
Issue number9
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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    Tabaton, M., Rolleri, M., Masturzo, P., Cammarata, S., Angelini, G., Hansen, L. A., Saitoh, T., Petersen, R. B., Perry, G., Richey, P., Gambetti, P., & Bertolini, S. (1995). Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy. Neurology, 45(9), 1764-1765.