Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy

M. Tabaton, M. Rolleri, P. Masturzo, S. Cammarata, G. Angelini, L. A. Hansen, T. Saitoh, R. B. Petersen, G. Perry, P. Richey, P. Gambetti, S. Bertolini

Research output: Contribution to journalArticle

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Abstract

We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This suggests that in Alzheimer's disease the increased frequency of ApoE element 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition.

Original languageEnglish
Pages (from-to)1764-1765
Number of pages2
JournalNeurology
Volume45
Issue number9
Publication statusPublished - 1995

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Progressive Supranuclear Palsy
Apolipoproteins
Apolipoproteins E
Gene Frequency
Apolipoprotein E4
Neurofibrillary Tangles
Amyloid Plaques
Amyloid
Neurodegenerative Diseases
Alzheimer Disease
Allele

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tabaton, M., Rolleri, M., Masturzo, P., Cammarata, S., Angelini, G., Hansen, L. A., ... Bertolini, S. (1995). Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy. Neurology, 45(9), 1764-1765.

Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy. / Tabaton, M.; Rolleri, M.; Masturzo, P.; Cammarata, S.; Angelini, G.; Hansen, L. A.; Saitoh, T.; Petersen, R. B.; Perry, G.; Richey, P.; Gambetti, P.; Bertolini, S.

In: Neurology, Vol. 45, No. 9, 1995, p. 1764-1765.

Research output: Contribution to journalArticle

Tabaton, M, Rolleri, M, Masturzo, P, Cammarata, S, Angelini, G, Hansen, LA, Saitoh, T, Petersen, RB, Perry, G, Richey, P, Gambetti, P & Bertolini, S 1995, 'Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy', Neurology, vol. 45, no. 9, pp. 1764-1765.
Tabaton M, Rolleri M, Masturzo P, Cammarata S, Angelini G, Hansen LA et al. Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy. Neurology. 1995;45(9):1764-1765.
Tabaton, M. ; Rolleri, M. ; Masturzo, P. ; Cammarata, S. ; Angelini, G. ; Hansen, L. A. ; Saitoh, T. ; Petersen, R. B. ; Perry, G. ; Richey, P. ; Gambetti, P. ; Bertolini, S. / Apolipoprotein e element 4 allele frequency is not increased in progressive supranuclear palsy. In: Neurology. 1995 ; Vol. 45, No. 9. pp. 1764-1765.
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AU - Rolleri, M.

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AU - Angelini, G.

AU - Hansen, L. A.

AU - Saitoh, T.

AU - Petersen, R. B.

AU - Perry, G.

AU - Richey, P.

AU - Gambetti, P.

AU - Bertolini, S.

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