Apolipoprotein E genotype does not influence the progression of multiple sclerosis

Giovanni Savettieri, Virginia Andreoli, Simona Bonavita, Rita Cittadella, Carlo Caltagirone, Maria Carolina Fazio, Paolo Girlanda, Francesco Le Pira, Maria Liguori, Giancarlo Logroscino, Alessandra Lugaresi, Ugo Nocentini, Arturo Reggio, Giuseppe Salemi, Paolo Serra, Gioacchino Tedeschi, Lucia Toma, Maria Trojano, Paola Valentino, Aldo Quattrone

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS. Methods: We investigated 428 subjects affected by clinically defined MS, with a disease duration of at least three years. We collected data concerning the age at onset of MS, clinical type, disease duration and disability according to the expanded disability status scale (EDSS). We also calculated the progression index (PI) to evaluate disease progression. APOE genotyping and the -491 A/T polymorphism of the APOE promoter were determined. Results: No association was observed between the APOE ε4 allele and clinical characteristics of our study population. We also investigated the -491 A/T APOE promoter polymorphism in 236 MS subjects and did not find any association between the -491 A/T polymorphism and the selected clinical variables. Conclusions: In our population the APOE ε4 allele and the -491 A/T APOE promoter polymorphism are not associated with a more rapid course of MS.

Original languageEnglish
Pages (from-to)1094-1098
Number of pages5
JournalJournal of Neurology
Issue number9
Publication statusPublished - Sep 1 2003


  • APOE polymorphism
  • APOE promoter
  • MS progression
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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