Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease

R. M. Ruggieri, R. Palermo, P. Calanni, G. Forlani, U. Lucca, E. Greco, F. Piccioli

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Abstract

Forty-one Sicilian patients (22 men and 19 women) suffering from probable Alzheimer's disease (according to NINCS-ADRDA criteria) underwent APO-E genotype examination. The mean age of onset was 69.3 (DS = 6.69), and the mean period of education was 7.41 (SD = 4.18) years. Twenty-one patients reported family history of cognitive decline. Results showed that at least l allele E4 was present in 50% of patients (14: E3/4; 6: E4/4). We did not find any correlation either with age of onset (p = 0.141) or with family history (p = 0.882). These preliminary data suggest a higher percentage of E4 allele in our group of patients compared to other authors' reports (Poinier et al., 1993; Frisoni et al., 1995).

Original languageEnglish
Pages (from-to)272
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume20
Issue number4
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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