Forty-one Sicilian patients (22 men and 19 women) suffering from probable Alzheimer's disease (according to NINCS-ADRDA criteria) underwent APO-E genotype examination. The mean age of onset was 69.3 (DS = 6.69), and the mean period of education was 7.41 (SD = 4.18) years. Twenty-one patients reported family history of cognitive decline. Results showed that at least l allele E4 was present in 50% of patients (14: E3/4; 6: E4/4). We did not find any correlation either with age of onset (p = 0.141) or with family history (p = 0.882). These preliminary data suggest a higher percentage of E4 allele in our group of patients compared to other authors' reports (Poinier et al., 1993; Frisoni et al., 1995).
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Clinical Neurology