Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease

R. M. Ruggieri, R. Palermo, P. Calanni, G. Forlani, U. Lucca, E. Greco, F. Piccioli

Research output: Contribution to journalArticle

Abstract

Forty-one Sicilian patients (22 men and 19 women) suffering from probable Alzheimer's disease (according to NINCS-ADRDA criteria) underwent APO-E genotype examination. The mean age of onset was 69.3 (DS = 6.69), and the mean period of education was 7.41 (SD = 4.18) years. Twenty-one patients reported family history of cognitive decline. Results showed that at least l allele E4 was present in 50% of patients (14: E3/4; 6: E4/4). We did not find any correlation either with age of onset (p = 0.141) or with family history (p = 0.882). These preliminary data suggest a higher percentage of E4 allele in our group of patients compared to other authors' reports (Poinier et al., 1993; Frisoni et al., 1995).

Original languageEnglish
Pages (from-to)272
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume20
Issue number4
Publication statusPublished - 1999

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Apolipoproteins
Alzheimer Disease
Genotype
Age of Onset
Alleles
Education

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Ruggieri, R. M., Palermo, R., Calanni, P., Forlani, G., Lucca, U., Greco, E., & Piccioli, F. (1999). Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease. Italian Journal of Neurological Sciences, 20(4), 272.

Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease. / Ruggieri, R. M.; Palermo, R.; Calanni, P.; Forlani, G.; Lucca, U.; Greco, E.; Piccioli, F.

In: Italian Journal of Neurological Sciences, Vol. 20, No. 4, 1999, p. 272.

Research output: Contribution to journalArticle

Ruggieri, RM, Palermo, R, Calanni, P, Forlani, G, Lucca, U, Greco, E & Piccioli, F 1999, 'Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease', Italian Journal of Neurological Sciences, vol. 20, no. 4, pp. 272.
Ruggieri RM, Palermo R, Calanni P, Forlani G, Lucca U, Greco E et al. Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease. Italian Journal of Neurological Sciences. 1999;20(4):272.
Ruggieri, R. M. ; Palermo, R. ; Calanni, P. ; Forlani, G. ; Lucca, U. ; Greco, E. ; Piccioli, F. / Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease. In: Italian Journal of Neurological Sciences. 1999 ; Vol. 20, No. 4. pp. 272.
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