Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease

R. M. Ruggieri; R. Palermo; P. Calanni; G. Forlani; U. Lucca; E. Greco; F. Piccioli

Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease

R. M. Ruggieri, R. Palermo, P. Calanni, G. Forlani, U. Lucca, E. Greco, F. Piccioli

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Forty-one Sicilian patients (22 men and 19 women) suffering from probable Alzheimer's disease (according to NINCS-ADRDA criteria) underwent APO-E genotype examination. The mean age of onset was 69.3 (DS = 6.69), and the mean period of education was 7.41 (SD = 4.18) years. Twenty-one patients reported family history of cognitive decline. Results showed that at least l allele E4 was present in 50% of patients (14: E3/4; 6: E4/4). We did not find any correlation either with age of onset (p = 0.141) or with family history (p = 0.882). These preliminary data suggest a higher percentage of E4 allele in our group of patients compared to other authors' reports (Poinier et al., 1993; Frisoni et al., 1995).

Original language	English
Pages (from-to)	272
Number of pages	1
Journal	Italian Journal of Neurological Sciences
Volume	20
Issue number	4
Publication status	Published - 1999

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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title = "Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease",

abstract = "Forty-one Sicilian patients (22 men and 19 women) suffering from probable Alzheimer's disease (according to NINCS-ADRDA criteria) underwent APO-E genotype examination. The mean age of onset was 69.3 (DS = 6.69), and the mean period of education was 7.41 (SD = 4.18) years. Twenty-one patients reported family history of cognitive decline. Results showed that at least l allele E4 was present in 50% of patients (14: E3/4; 6: E4/4). We did not find any correlation either with age of onset (p = 0.141) or with family history (p = 0.882). These preliminary data suggest a higher percentage of E4 allele in our group of patients compared to other authors' reports (Poinier et al., 1993; Frisoni et al., 1995).",

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T1 - Apolipoprotein e genotype in a sample of Sicilian patients suffering from Alzheimer's disease

AU - Ruggieri, R. M.

AU - Palermo, R.

AU - Calanni, P.

AU - Forlani, G.

AU - Lucca, U.

AU - Greco, E.

AU - Piccioli, F.

PY - 1999

Y1 - 1999

N2 - Forty-one Sicilian patients (22 men and 19 women) suffering from probable Alzheimer's disease (according to NINCS-ADRDA criteria) underwent APO-E genotype examination. The mean age of onset was 69.3 (DS = 6.69), and the mean period of education was 7.41 (SD = 4.18) years. Twenty-one patients reported family history of cognitive decline. Results showed that at least l allele E4 was present in 50% of patients (14: E3/4; 6: E4/4). We did not find any correlation either with age of onset (p = 0.141) or with family history (p = 0.882). These preliminary data suggest a higher percentage of E4 allele in our group of patients compared to other authors' reports (Poinier et al., 1993; Frisoni et al., 1995).

AB - Forty-one Sicilian patients (22 men and 19 women) suffering from probable Alzheimer's disease (according to NINCS-ADRDA criteria) underwent APO-E genotype examination. The mean age of onset was 69.3 (DS = 6.69), and the mean period of education was 7.41 (SD = 4.18) years. Twenty-one patients reported family history of cognitive decline. Results showed that at least l allele E4 was present in 50% of patients (14: E3/4; 6: E4/4). We did not find any correlation either with age of onset (p = 0.141) or with family history (p = 0.882). These preliminary data suggest a higher percentage of E4 allele in our group of patients compared to other authors' reports (Poinier et al., 1993; Frisoni et al., 1995).

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