Apolipoprotein E genotype in senile dementia and Down's syndrome

Giorgio Annoni, Ludovica Caputo, Anthony Ryan, Mariagrazia Cova, Margherita Casartelli, Carlo Vergani

Research output: Contribution to journalArticlepeer-review


Apolipoprotein E genotypes were determined in 30 healthy elderly controls, 42 patients with Alzheimer's disease, 13 subjects with vascular dementia and 31 individuals with Down's syndrome. The frequency of ε4 allele carriers was significantly increased in the Alzheimer's disease group (χ2 = 4.918, P <0.05) but also in the vascular dementia subjects (P <0.01, Fisher's exact test). The established relationship between genotype and age at onset of Alzheimer's disease was not statistically significant in these data. Frequencies of the genotypes in the Down's syndrome group did not differ from those of controls. The results obtained in this sample of the Italian population suggest that the apolipoprotein E genotype may be of limited use in the differential diagnosis of dementia.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalArchives of Gerontology and Geriatrics
Issue number1
Publication statusPublished - Dec 1997


  • Alzheimer's disease
  • Apolipoprotein E genotype
  • Down's syndrome
  • Vascular dementia

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)


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