Abstract
Apolipoprotein E genotypes were determined in 30 healthy elderly controls, 42 patients with Alzheimer's disease, 13 subjects with vascular dementia and 31 individuals with Down's syndrome. The frequency of ε4 allele carriers was significantly increased in the Alzheimer's disease group (χ2 = 4.918, P <0.05) but also in the vascular dementia subjects (P <0.01, Fisher's exact test). The established relationship between genotype and age at onset of Alzheimer's disease was not statistically significant in these data. Frequencies of the genotypes in the Down's syndrome group did not differ from those of controls. The results obtained in this sample of the Italian population suggest that the apolipoprotein E genotype may be of limited use in the differential diagnosis of dementia.
| Original language | English |
|---|---|
| Pages (from-to) | 15-21 |
| Number of pages | 7 |
| Journal | Archives of Gerontology and Geriatrics |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1997 |
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Keywords
- Alzheimer's disease
- Apolipoprotein E genotype
- Down's syndrome
- Vascular dementia
ASJC Scopus subject areas
- Ageing
- Medicine(all)
Cite this
Apolipoprotein E genotype in senile dementia and Down's syndrome. / Annoni, Giorgio; Caputo, Ludovica; Ryan, Anthony; Cova, Mariagrazia; Casartelli, Margherita; Vergani, Carlo.
In: Archives of Gerontology and Geriatrics, Vol. 26, No. 1, 12.1997, p. 15-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apolipoprotein E genotype in senile dementia and Down's syndrome
AU - Annoni, Giorgio
AU - Caputo, Ludovica
AU - Ryan, Anthony
AU - Cova, Mariagrazia
AU - Casartelli, Margherita
AU - Vergani, Carlo
PY - 1997/12
Y1 - 1997/12
N2 - Apolipoprotein E genotypes were determined in 30 healthy elderly controls, 42 patients with Alzheimer's disease, 13 subjects with vascular dementia and 31 individuals with Down's syndrome. The frequency of ε4 allele carriers was significantly increased in the Alzheimer's disease group (χ2 = 4.918, P <0.05) but also in the vascular dementia subjects (P <0.01, Fisher's exact test). The established relationship between genotype and age at onset of Alzheimer's disease was not statistically significant in these data. Frequencies of the genotypes in the Down's syndrome group did not differ from those of controls. The results obtained in this sample of the Italian population suggest that the apolipoprotein E genotype may be of limited use in the differential diagnosis of dementia.
AB - Apolipoprotein E genotypes were determined in 30 healthy elderly controls, 42 patients with Alzheimer's disease, 13 subjects with vascular dementia and 31 individuals with Down's syndrome. The frequency of ε4 allele carriers was significantly increased in the Alzheimer's disease group (χ2 = 4.918, P <0.05) but also in the vascular dementia subjects (P <0.01, Fisher's exact test). The established relationship between genotype and age at onset of Alzheimer's disease was not statistically significant in these data. Frequencies of the genotypes in the Down's syndrome group did not differ from those of controls. The results obtained in this sample of the Italian population suggest that the apolipoprotein E genotype may be of limited use in the differential diagnosis of dementia.
KW - Alzheimer's disease
KW - Apolipoprotein E genotype
KW - Down's syndrome
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=0030784841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030784841&partnerID=8YFLogxK
U2 - 10.1016/S0167-4943(97)00025-3
DO - 10.1016/S0167-4943(97)00025-3
M3 - Article
C2 - 18653122
AN - SCOPUS:0030784841
VL - 26
SP - 15
EP - 21
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 1
ER -