Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.
|Number of pages||6|
|Journal||Current Opinion in Lipidology|
|Publication status||Published - 1995|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)