Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort

P. Cerrato, C. Baima, M. Grasso, A. Lentini, G. Bosco, M. Cassader, R. Gambino, P. Cavallo Perin, G. Pagano, P. Fornengo, D. Imperiale, B. Bergamasco, G. Bruno

Research output: Contribution to journalArticle

Abstract

Background: Studies have indicated that apolipoprotein E (ApoE)-ε4 is a risk factor for ischemic cerebrovascular diseases (ICVD), but the existence of this association is still controversial. The aims of this study were: (1) to compare ApoE genotype and allele frequencies in Italian cases with ICVD and in healthy control subjects and (2) to compare ApoE allele frequencies among ischemic stroke subtypes. Methods: A hospital-based cohort of 302 Italian subjects with ICVD and 228 healthy subjects have been recruited to investigate the role of ApoE polymorphisms as risk factors for ICVD. TOAST criteria were employed to stratify ICVD cases by subtypes. Results: No significant differences in ApoE genotype and allele frequencies were found between cases and control subjects. The frequency of ApoE-ε4 was lower in cases than in control subjects (6% vs. 10.1%), although not significantly. No differences in ApoE genotype and allele frequencies were evident among ICVD subtypes. However, out of 36 ApoE-ε4 alleles 23 (3.7%) were found in subjects with ICVD related to primary degenerative arterial disease related to large vessel disease and small vessel disease, and 13 (2.1%) in remaining subjects. Using logistic regression analysis we assessed whether ApoE-ε4 allele was independently associated with risk of ICVD related to a primary degenerative arterial disease compared to other ICVD subtypes. While classical risk factors were significantly associated with higher risk for ICVD due to large vessel disease and small vessel disease than other ICVD subtypes, the role of ApoE-ε4 allele was not significant (OR 1.25, 95% CI 0.57-2.74). Conclusion: Our study shows similar ApoE-ε4 genotype and allele frequencies in patients with ICVD and in control subjects. No differences were found among different ICVD subtypes either.

Original languageEnglish
Pages (from-to)264-269
Number of pages6
JournalCerebrovascular Diseases
Volume20
Issue number4
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Cerebrovascular Disorders
Apolipoproteins E
Stroke
Apolipoprotein E4
Gene Frequency
Genotype
Alleles
Healthy Volunteers

Keywords

  • Apolipoprotein E
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Cerrato, P., Baima, C., Grasso, M., Lentini, A., Bosco, G., Cassader, M., ... Bruno, G. (2005). Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort. Cerebrovascular Diseases, 20(4), 264-269. https://doi.org/10.1159/000087709

Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort. / Cerrato, P.; Baima, C.; Grasso, M.; Lentini, A.; Bosco, G.; Cassader, M.; Gambino, R.; Cavallo Perin, P.; Pagano, G.; Fornengo, P.; Imperiale, D.; Bergamasco, B.; Bruno, G.

In: Cerebrovascular Diseases, Vol. 20, No. 4, 09.2005, p. 264-269.

Research output: Contribution to journalArticle

Cerrato, P, Baima, C, Grasso, M, Lentini, A, Bosco, G, Cassader, M, Gambino, R, Cavallo Perin, P, Pagano, G, Fornengo, P, Imperiale, D, Bergamasco, B & Bruno, G 2005, 'Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort', Cerebrovascular Diseases, vol. 20, no. 4, pp. 264-269. https://doi.org/10.1159/000087709
Cerrato, P. ; Baima, C. ; Grasso, M. ; Lentini, A. ; Bosco, G. ; Cassader, M. ; Gambino, R. ; Cavallo Perin, P. ; Pagano, G. ; Fornengo, P. ; Imperiale, D. ; Bergamasco, B. ; Bruno, G. / Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort. In: Cerebrovascular Diseases. 2005 ; Vol. 20, No. 4. pp. 264-269.
@article{775209ec92b5442c901acecb772c46c7,
title = "Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort",
abstract = "Background: Studies have indicated that apolipoprotein E (ApoE)-ε4 is a risk factor for ischemic cerebrovascular diseases (ICVD), but the existence of this association is still controversial. The aims of this study were: (1) to compare ApoE genotype and allele frequencies in Italian cases with ICVD and in healthy control subjects and (2) to compare ApoE allele frequencies among ischemic stroke subtypes. Methods: A hospital-based cohort of 302 Italian subjects with ICVD and 228 healthy subjects have been recruited to investigate the role of ApoE polymorphisms as risk factors for ICVD. TOAST criteria were employed to stratify ICVD cases by subtypes. Results: No significant differences in ApoE genotype and allele frequencies were found between cases and control subjects. The frequency of ApoE-ε4 was lower in cases than in control subjects (6{\%} vs. 10.1{\%}), although not significantly. No differences in ApoE genotype and allele frequencies were evident among ICVD subtypes. However, out of 36 ApoE-ε4 alleles 23 (3.7{\%}) were found in subjects with ICVD related to primary degenerative arterial disease related to large vessel disease and small vessel disease, and 13 (2.1{\%}) in remaining subjects. Using logistic regression analysis we assessed whether ApoE-ε4 allele was independently associated with risk of ICVD related to a primary degenerative arterial disease compared to other ICVD subtypes. While classical risk factors were significantly associated with higher risk for ICVD due to large vessel disease and small vessel disease than other ICVD subtypes, the role of ApoE-ε4 allele was not significant (OR 1.25, 95{\%} CI 0.57-2.74). Conclusion: Our study shows similar ApoE-ε4 genotype and allele frequencies in patients with ICVD and in control subjects. No differences were found among different ICVD subtypes either.",
keywords = "Apolipoprotein E, Risk factors, Stroke",
author = "P. Cerrato and C. Baima and M. Grasso and A. Lentini and G. Bosco and M. Cassader and R. Gambino and {Cavallo Perin}, P. and G. Pagano and P. Fornengo and D. Imperiale and B. Bergamasco and G. Bruno",
year = "2005",
month = "9",
doi = "10.1159/000087709",
language = "English",
volume = "20",
pages = "264--269",
journal = "Cerebrovascular Diseases",
issn = "1015-9770",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort

AU - Cerrato, P.

AU - Baima, C.

AU - Grasso, M.

AU - Lentini, A.

AU - Bosco, G.

AU - Cassader, M.

AU - Gambino, R.

AU - Cavallo Perin, P.

AU - Pagano, G.

AU - Fornengo, P.

AU - Imperiale, D.

AU - Bergamasco, B.

AU - Bruno, G.

PY - 2005/9

Y1 - 2005/9

N2 - Background: Studies have indicated that apolipoprotein E (ApoE)-ε4 is a risk factor for ischemic cerebrovascular diseases (ICVD), but the existence of this association is still controversial. The aims of this study were: (1) to compare ApoE genotype and allele frequencies in Italian cases with ICVD and in healthy control subjects and (2) to compare ApoE allele frequencies among ischemic stroke subtypes. Methods: A hospital-based cohort of 302 Italian subjects with ICVD and 228 healthy subjects have been recruited to investigate the role of ApoE polymorphisms as risk factors for ICVD. TOAST criteria were employed to stratify ICVD cases by subtypes. Results: No significant differences in ApoE genotype and allele frequencies were found between cases and control subjects. The frequency of ApoE-ε4 was lower in cases than in control subjects (6% vs. 10.1%), although not significantly. No differences in ApoE genotype and allele frequencies were evident among ICVD subtypes. However, out of 36 ApoE-ε4 alleles 23 (3.7%) were found in subjects with ICVD related to primary degenerative arterial disease related to large vessel disease and small vessel disease, and 13 (2.1%) in remaining subjects. Using logistic regression analysis we assessed whether ApoE-ε4 allele was independently associated with risk of ICVD related to a primary degenerative arterial disease compared to other ICVD subtypes. While classical risk factors were significantly associated with higher risk for ICVD due to large vessel disease and small vessel disease than other ICVD subtypes, the role of ApoE-ε4 allele was not significant (OR 1.25, 95% CI 0.57-2.74). Conclusion: Our study shows similar ApoE-ε4 genotype and allele frequencies in patients with ICVD and in control subjects. No differences were found among different ICVD subtypes either.

AB - Background: Studies have indicated that apolipoprotein E (ApoE)-ε4 is a risk factor for ischemic cerebrovascular diseases (ICVD), but the existence of this association is still controversial. The aims of this study were: (1) to compare ApoE genotype and allele frequencies in Italian cases with ICVD and in healthy control subjects and (2) to compare ApoE allele frequencies among ischemic stroke subtypes. Methods: A hospital-based cohort of 302 Italian subjects with ICVD and 228 healthy subjects have been recruited to investigate the role of ApoE polymorphisms as risk factors for ICVD. TOAST criteria were employed to stratify ICVD cases by subtypes. Results: No significant differences in ApoE genotype and allele frequencies were found between cases and control subjects. The frequency of ApoE-ε4 was lower in cases than in control subjects (6% vs. 10.1%), although not significantly. No differences in ApoE genotype and allele frequencies were evident among ICVD subtypes. However, out of 36 ApoE-ε4 alleles 23 (3.7%) were found in subjects with ICVD related to primary degenerative arterial disease related to large vessel disease and small vessel disease, and 13 (2.1%) in remaining subjects. Using logistic regression analysis we assessed whether ApoE-ε4 allele was independently associated with risk of ICVD related to a primary degenerative arterial disease compared to other ICVD subtypes. While classical risk factors were significantly associated with higher risk for ICVD due to large vessel disease and small vessel disease than other ICVD subtypes, the role of ApoE-ε4 allele was not significant (OR 1.25, 95% CI 0.57-2.74). Conclusion: Our study shows similar ApoE-ε4 genotype and allele frequencies in patients with ICVD and in control subjects. No differences were found among different ICVD subtypes either.

KW - Apolipoprotein E

KW - Risk factors

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=24944525775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24944525775&partnerID=8YFLogxK

U2 - 10.1159/000087709

DO - 10.1159/000087709

M3 - Article

C2 - 16123547

AN - SCOPUS:24944525775

VL - 20

SP - 264

EP - 269

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

SN - 1015-9770

IS - 4

ER -