Apolipoprotein E-related all-cause mortality in hospitalized elderly patients

Maria G. Matera, Daniele Sancarlo, Francesco Panza, Carolina Gravina, Grazia D'Onofrio, Vincenza Frisardi, Grazia Longo, Luigi P. D'Ambrosio, Filomena Addante, Massimiliano Copetti, Vincenzo Solfrizzi, Davide Seripa, Alberto Pilotto

Research output: Contribution to journalArticlepeer-review


The most common apolipoprotein E (APOE) allelic variation is implicated in many age-related diseases and human longevity with controversial findings. We investigated the effect of APOE gene polymorphism on all-cause mortality in elderly patients taking into consideration the functional disability, cognitive impairment, malnutrition, and the occurrence of common age-related diseases. APOE genotypes were determined in 2,124 geriatric hospitalized patients (46.5% men and 53.5% women; mean age, 78.2±7.1 years; range, 65-100 years). At hospital admission, all patients underwent a comprehensive geriatric assessment to evaluate functional disability, cognitive status, nutritional status, and comorbidity. The main and secondary diagnoses at hospital discharge were also recorded. Mortality status was evaluated in all patients after a maximum follow-up of 5 years (range, from 1.26 to 5.23 years; median, 2.86 years). During the study period, 671 patients died (32.0%). At hospital admission, these patients showed a significant higher prevalence of cardiovascular diseases (56.3% vs 53.4%; p=0.007), neoplasias (32.3% vs 13.7%; p

Original languageEnglish
Pages (from-to)411-420
Number of pages10
Issue number3
Publication statusPublished - Sep 2010


  • Apolipoprotein E
  • Cardiovascular aging
  • Dementia
  • Mortality

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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