Abstract
Lipoprotein(a) [Lp(a)] is an atherogenic and prothrombotic molecule formed by the covalent binding of the highly polymorphic apolipoprotein(a) [apo(a)] to apoprotein B-100 of LDL. High Lp(a) concentrations are a recognized genetic risk factor for coronary heart disease (CHD) and have been shown to be related with a familial clustering of ischemic cardiac events. Nevertheless, the association between apolipoprotein(a) isoforms and a positive familial history of CHD has received far less attention. In this report, we explored the distribution of apo(a) phenotypes in 127 CHD subjects with a family history of coronary events and in 92 CHD patients without such a history. Twenty-two apo(a) isoforms were detected by a high-resolution immunoblotting method. In univariate analysis, the percentage of subjects with at least one small sized apo(a) isoform was significantly higher in CHD patients with a positive family history than in those without (P
| Original language | English |
|---|---|
| Pages (from-to) | 243-247 |
| Number of pages | 5 |
| Journal | International Journal of Molecular Medicine |
| Volume | 13 |
| Issue number | 2 |
| Publication status | Published - Feb 2004 |
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ASJC Scopus subject areas
- Genetics
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Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease. / Peros, Emmanouil; Geroldi, Diego; D'Angelo, Angela; Falcone, Colomba; Montagna, Lorenza; Carabela, Maria; Emanuele, Enzo.
In: International Journal of Molecular Medicine, Vol. 13, No. 2, 02.2004, p. 243-247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease.
AU - Peros, Emmanouil
AU - Geroldi, Diego
AU - D'Angelo, Angela
AU - Falcone, Colomba
AU - Montagna, Lorenza
AU - Carabela, Maria
AU - Emanuele, Enzo
PY - 2004/2
Y1 - 2004/2
N2 - Lipoprotein(a) [Lp(a)] is an atherogenic and prothrombotic molecule formed by the covalent binding of the highly polymorphic apolipoprotein(a) [apo(a)] to apoprotein B-100 of LDL. High Lp(a) concentrations are a recognized genetic risk factor for coronary heart disease (CHD) and have been shown to be related with a familial clustering of ischemic cardiac events. Nevertheless, the association between apolipoprotein(a) isoforms and a positive familial history of CHD has received far less attention. In this report, we explored the distribution of apo(a) phenotypes in 127 CHD subjects with a family history of coronary events and in 92 CHD patients without such a history. Twenty-two apo(a) isoforms were detected by a high-resolution immunoblotting method. In univariate analysis, the percentage of subjects with at least one small sized apo(a) isoform was significantly higher in CHD patients with a positive family history than in those without (P
AB - Lipoprotein(a) [Lp(a)] is an atherogenic and prothrombotic molecule formed by the covalent binding of the highly polymorphic apolipoprotein(a) [apo(a)] to apoprotein B-100 of LDL. High Lp(a) concentrations are a recognized genetic risk factor for coronary heart disease (CHD) and have been shown to be related with a familial clustering of ischemic cardiac events. Nevertheless, the association between apolipoprotein(a) isoforms and a positive familial history of CHD has received far less attention. In this report, we explored the distribution of apo(a) phenotypes in 127 CHD subjects with a family history of coronary events and in 92 CHD patients without such a history. Twenty-two apo(a) isoforms were detected by a high-resolution immunoblotting method. In univariate analysis, the percentage of subjects with at least one small sized apo(a) isoform was significantly higher in CHD patients with a positive family history than in those without (P
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M3 - Article
VL - 13
SP - 243
EP - 247
JO - International Journal of Molecular Medicine
JF - International Journal of Molecular Medicine
SN - 1107-3756
IS - 2
ER -