Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease.

Emmanouil Peros, Diego Geroldi, Angela D'Angelo, Colomba Falcone, Lorenza Montagna, Maria Carabela, Enzo Emanuele

Research output: Contribution to journalArticle

Abstract

Lipoprotein(a) [Lp(a)] is an atherogenic and prothrombotic molecule formed by the covalent binding of the highly polymorphic apolipoprotein(a) [apo(a)] to apoprotein B-100 of LDL. High Lp(a) concentrations are a recognized genetic risk factor for coronary heart disease (CHD) and have been shown to be related with a familial clustering of ischemic cardiac events. Nevertheless, the association between apolipoprotein(a) isoforms and a positive familial history of CHD has received far less attention. In this report, we explored the distribution of apo(a) phenotypes in 127 CHD subjects with a family history of coronary events and in 92 CHD patients without such a history. Twenty-two apo(a) isoforms were detected by a high-resolution immunoblotting method. In univariate analysis, the percentage of subjects with at least one small sized apo(a) isoform was significantly higher in CHD patients with a positive family history than in those without (P

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalInternational Journal of Molecular Medicine
Volume13
Issue number2
Publication statusPublished - Feb 2004

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ASJC Scopus subject areas

  • Genetics

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