Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease.

Emmanouil Peros, Diego Geroldi, Angela D'Angelo, Colomba Falcone, Lorenza Montagna, Maria Carabela, Enzo Emanuele

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Lipoprotein(a) [Lp(a)] is an atherogenic and prothrombotic molecule formed by the covalent binding of the highly polymorphic apolipoprotein(a) [apo(a)] to apoprotein B-100 of LDL. High Lp(a) concentrations are a recognized genetic risk factor for coronary heart disease (CHD) and have been shown to be related with a familial clustering of ischemic cardiac events. Nevertheless, the association between apolipoprotein(a) isoforms and a positive familial history of CHD has received far less attention. In this report, we explored the distribution of apo(a) phenotypes in 127 CHD subjects with a family history of coronary events and in 92 CHD patients without such a history. Twenty-two apo(a) isoforms were detected by a high-resolution immunoblotting method. In univariate analysis, the percentage of subjects with at least one small sized apo(a) isoform was significantly higher in CHD patients with a positive family history than in those without (P

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalInternational Journal of Molecular Medicine
Volume13
Issue number2
Publication statusPublished - Feb 2004

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Apoprotein(a)
Coronary Disease
Biomarkers
Phenotype
Protein Isoforms
Lipoprotein(a)
Apolipoproteins B
Immunoblotting
Cluster Analysis
History

ASJC Scopus subject areas

  • Genetics

Cite this

Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease. / Peros, Emmanouil; Geroldi, Diego; D'Angelo, Angela; Falcone, Colomba; Montagna, Lorenza; Carabela, Maria; Emanuele, Enzo.

In: International Journal of Molecular Medicine, Vol. 13, No. 2, 02.2004, p. 243-247.

Research output: Contribution to journalArticle

Peros, E, Geroldi, D, D'Angelo, A, Falcone, C, Montagna, L, Carabela, M & Emanuele, E 2004, 'Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease.', International Journal of Molecular Medicine, vol. 13, no. 2, pp. 243-247.
Peros, Emmanouil ; Geroldi, Diego ; D'Angelo, Angela ; Falcone, Colomba ; Montagna, Lorenza ; Carabela, Maria ; Emanuele, Enzo. / Apolipoprotein(a) phenotypes are reliable biomarkers for familial aggregation of coronary heart disease. In: International Journal of Molecular Medicine. 2004 ; Vol. 13, No. 2. pp. 243-247.
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AU - Carabela, Maria

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