Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes.

Richard W. Browne, Bianca Weinstock-Guttman, Dana Horakova, Robert Zivadinov, Mary Lou Bodziak, Miriam Tamaño-Blanco, Darlene Badgett, Michaela Tyblova, Manuela Vaneckova, Zdenek Seidl, Jan Krasensky, Niels Bergsland, Deepa P. Ramasamy, Jesper Hagemeier, Eva Havrdova, Murali Ramanathan

Research output: Contribution to journalArticle

Abstract

There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1±SD 8.1 years). All patients were treated with intramuscular interferon-β as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-β treatment. Greater ApoB levels were associated with increased number of new T2 lesions (p

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume85
Issue number8
Publication statusPublished - 2014

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Apolipoproteins
Atrophy
Apolipoproteins B
Interferons
Disease Progression
Serum
Lipoprotein(a)
Apolipoproteins E
Biomarkers
Prospective Studies
Ligands
Therapeutics
Gray Matter
lipoprotein cholesterol

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Browne, R. W., Weinstock-Guttman, B., Horakova, D., Zivadinov, R., Bodziak, M. L., Tamaño-Blanco, M., ... Ramanathan, M. (2014). Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. Journal of Neurology, Neurosurgery and Psychiatry, 85(8), 859-864.

Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. / Browne, Richard W.; Weinstock-Guttman, Bianca; Horakova, Dana; Zivadinov, Robert; Bodziak, Mary Lou; Tamaño-Blanco, Miriam; Badgett, Darlene; Tyblova, Michaela; Vaneckova, Manuela; Seidl, Zdenek; Krasensky, Jan; Bergsland, Niels; Ramasamy, Deepa P.; Hagemeier, Jesper; Havrdova, Eva; Ramanathan, Murali.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 85, No. 8, 2014, p. 859-864.

Research output: Contribution to journalArticle

Browne, RW, Weinstock-Guttman, B, Horakova, D, Zivadinov, R, Bodziak, ML, Tamaño-Blanco, M, Badgett, D, Tyblova, M, Vaneckova, M, Seidl, Z, Krasensky, J, Bergsland, N, Ramasamy, DP, Hagemeier, J, Havrdova, E & Ramanathan, M 2014, 'Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes.', Journal of Neurology, Neurosurgery and Psychiatry, vol. 85, no. 8, pp. 859-864.
Browne RW, Weinstock-Guttman B, Horakova D, Zivadinov R, Bodziak ML, Tamaño-Blanco M et al. Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. Journal of Neurology, Neurosurgery and Psychiatry. 2014;85(8):859-864.
Browne, Richard W. ; Weinstock-Guttman, Bianca ; Horakova, Dana ; Zivadinov, Robert ; Bodziak, Mary Lou ; Tamaño-Blanco, Miriam ; Badgett, Darlene ; Tyblova, Michaela ; Vaneckova, Manuela ; Seidl, Zdenek ; Krasensky, Jan ; Bergsland, Niels ; Ramasamy, Deepa P. ; Hagemeier, Jesper ; Havrdova, Eva ; Ramanathan, Murali. / Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. In: Journal of Neurology, Neurosurgery and Psychiatry. 2014 ; Vol. 85, No. 8. pp. 859-864.
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AU - Bodziak, Mary Lou

AU - Tamaño-Blanco, Miriam

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AU - Krasensky, Jan

AU - Bergsland, Niels

AU - Ramasamy, Deepa P.

AU - Hagemeier, Jesper

AU - Havrdova, Eva

AU - Ramanathan, Murali

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