Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes

Richard W. Browne, Bianca Weinstock-Guttman, Dana Horakova, Robert Zivadinov, Mary Lou Bodziak, Miriam Tamaño-Blanco, Darlene Badgett, Michaela Tyblova, Manuela Vaneckova, Zdenek Seidl, Jan Krasensky, Niels Bergsland, Deepa P. Ramasamy, Jesper Hagemeier, Eva Havrdova, Murali Ramanathan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1±SD 8.1 years). All patients were treated with intramuscular interferon-β as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-β treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (pp=-0.28, p

Original languageEnglish
Pages (from-to)860-865
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume85
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Apolipoproteins
Atrophy
Apolipoproteins B
Interferons
Disease Progression
Serum
Lipoprotein(a)
Apolipoproteins E
Biomarkers
Prospective Studies
Ligands
Therapeutics
Gray Matter
Lesion
Grey Matter
Syndrome
lipoprotein cholesterol
Cholesterol
Progression

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

Browne, R. W., Weinstock-Guttman, B., Horakova, D., Zivadinov, R., Bodziak, M. L., Tamaño-Blanco, M., ... Ramanathan, M. (2014). Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. Journal of Neurology, Neurosurgery and Psychiatry, 85(8), 860-865. https://doi.org/10.1136/jnnp-2013-307106

Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. / Browne, Richard W.; Weinstock-Guttman, Bianca; Horakova, Dana; Zivadinov, Robert; Bodziak, Mary Lou; Tamaño-Blanco, Miriam; Badgett, Darlene; Tyblova, Michaela; Vaneckova, Manuela; Seidl, Zdenek; Krasensky, Jan; Bergsland, Niels; Ramasamy, Deepa P.; Hagemeier, Jesper; Havrdova, Eva; Ramanathan, Murali.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 85, No. 8, 2014, p. 860-865.

Research output: Contribution to journalArticle

Browne, RW, Weinstock-Guttman, B, Horakova, D, Zivadinov, R, Bodziak, ML, Tamaño-Blanco, M, Badgett, D, Tyblova, M, Vaneckova, M, Seidl, Z, Krasensky, J, Bergsland, N, Ramasamy, DP, Hagemeier, J, Havrdova, E & Ramanathan, M 2014, 'Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes', Journal of Neurology, Neurosurgery and Psychiatry, vol. 85, no. 8, pp. 860-865. https://doi.org/10.1136/jnnp-2013-307106
Browne, Richard W. ; Weinstock-Guttman, Bianca ; Horakova, Dana ; Zivadinov, Robert ; Bodziak, Mary Lou ; Tamaño-Blanco, Miriam ; Badgett, Darlene ; Tyblova, Michaela ; Vaneckova, Manuela ; Seidl, Zdenek ; Krasensky, Jan ; Bergsland, Niels ; Ramasamy, Deepa P. ; Hagemeier, Jesper ; Havrdova, Eva ; Ramanathan, Murali. / Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. In: Journal of Neurology, Neurosurgery and Psychiatry. 2014 ; Vol. 85, No. 8. pp. 860-865.
@article{039f436e9c3240e7a64aa0ae90174536,
title = "Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes",
abstract = "Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68{\%} women; mean age: 28.1±SD 8.1 years). All patients were treated with intramuscular interferon-β as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-β treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (pp=-0.28, p",
author = "Browne, {Richard W.} and Bianca Weinstock-Guttman and Dana Horakova and Robert Zivadinov and Bodziak, {Mary Lou} and Miriam Tama{\~n}o-Blanco and Darlene Badgett and Michaela Tyblova and Manuela Vaneckova and Zdenek Seidl and Jan Krasensky and Niels Bergsland and Ramasamy, {Deepa P.} and Jesper Hagemeier and Eva Havrdova and Murali Ramanathan",
year = "2014",
doi = "10.1136/jnnp-2013-307106",
language = "English",
volume = "85",
pages = "860--865",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "8",

}

TY - JOUR

T1 - Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes

AU - Browne, Richard W.

AU - Weinstock-Guttman, Bianca

AU - Horakova, Dana

AU - Zivadinov, Robert

AU - Bodziak, Mary Lou

AU - Tamaño-Blanco, Miriam

AU - Badgett, Darlene

AU - Tyblova, Michaela

AU - Vaneckova, Manuela

AU - Seidl, Zdenek

AU - Krasensky, Jan

AU - Bergsland, Niels

AU - Ramasamy, Deepa P.

AU - Hagemeier, Jesper

AU - Havrdova, Eva

AU - Ramanathan, Murali

PY - 2014

Y1 - 2014

N2 - Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1±SD 8.1 years). All patients were treated with intramuscular interferon-β as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-β treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (pp=-0.28, p

AB - Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1±SD 8.1 years). All patients were treated with intramuscular interferon-β as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-β treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (pp=-0.28, p

UR - http://www.scopus.com/inward/record.url?scp=84904183301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904183301&partnerID=8YFLogxK

U2 - 10.1136/jnnp-2013-307106

DO - 10.1136/jnnp-2013-307106

M3 - Article

AN - SCOPUS:84904183301

VL - 85

SP - 860

EP - 865

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 8

ER -