Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes

Richard W. Browne, Bianca Weinstock-Guttman, Dana Horakova, Robert Zivadinov, Mary Lou Bodziak, Miriam Tamaño-Blanco, Darlene Badgett, Michaela Tyblova, Manuela Vaneckova, Zdenek Seidl, Jan Krasensky, Niels Bergsland, Deepa P. Ramasamy, Jesper Hagemeier, Eva Havrdova, Murali Ramanathan

Research output: Contribution to journalArticlepeer-review


Objectives: There is increasing evidence that serum lipoprotein cholesterol biomarkers are associated with disease progression in clinically isolated syndromes (CIS). Apolipoproteins (Apo) are recognition ligands that mediate the physiological interactions of cholesterol-containing lipoproteins. The objective of this study was to investigate whether serum Apo levels are associated with CIS disease progression. Methods: ApoB, ApoAI, ApoAII, ApoE and lipoprotein (a) (Lpa) levels were measured in serum samples obtained prior to the start of treatment from 181 CIS patients (123 women, 58 men, 68% women; mean age: 28.1±SD 8.1 years). All patients were treated with intramuscular interferon-β as part of the prospective study. Clinical and MRI assessments were obtained at baseline, 6, 12 and 24 months after start of interferon-β treatment. Results: Greater ApoB levels were associated with increased number of new T2 lesions (pp=-0.28, p

Original languageEnglish
Pages (from-to)860-865
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number8
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)


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