Apomorphine and levodopa challenge in patients with a focal midbrain lesion

Elena Moro, Alberto Albanese

Research output: Contribution to journalArticlepeer-review


Three patients who presented with parkinsonian signs resulting from a focal midbrain lesion are reported. In all patients parkinsonian features occurred acutely and improved following acute challenge with apomorphine but not with levodopa. Remission of parkinsonian signs occurred spontaneously to a different degree. Inconsistent clinical response following administration of levodopa has been well documented in patients with focal midbrain lesions associated with parkinsonian signs; however, the efficacy of apomorphine has not been tested before. Anatomic or etiologic features do not allow us to predict in which cases parkinsonian signs secondary to a midbrain lesion would respond to levodopa or to dopamine agonists. A trial with apomorphine is warranted in all such cases.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalMovement Disorders
Issue number2
Publication statusPublished - 1999


  • Apomorphine
  • Levodopa
  • Mesencephalon
  • Movement disorders
  • Parkinson's disease
  • Secondary parkinsonism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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